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Kitamari (Aristolochia bracteata) Medicinal uses and pharmacology

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Kitamari (Aristolochia bracteata) Medicinal uses and pharmacology

Aristolochia bracteata-1.jpg

 

Kitamari- Aristolochia bracteolata is a herb mentioned in Ayurveda for the treatment of wound, intestinal worms, dysmenorrhea, skin diseases and fever. 

Latin name- Aristolochia bracteolata Retz. Aristolochia bracteata
Family- Aristolochiaceae

Names in different languages:
Hindi name – Kitamar

English name– Bracteated birthwort, Pipewine
Bengali name – Kiramar, Patuvanga
Gujarathi name- Kiramar
Kannada name – Adu Muttada gida
Malayalam name– Aduthinnappalai
Marathi name – Kidamar
Oriya name – Paniri
Tamil name – Aduthinnarppalai
Telugu name – Gadide, Gadaparaku
Urdu name- Paniri
Deccan – Gandan, Gandati

Keetamari – Sanskrit Synonyms
Dhumrapatra- The leaf is used for fumigation

Kitamari- Destroys the germs

Morphology of Aristolochia bracteolata:
This is a small herb growing to a height of 1-2 feet and is found all over India in the temperate climate. The stem is smooth and little twining. The branches are sharp and small. The leaves are 2- 3 inch long, kidney shaped and membranous. The under-surface has small mesh like structure. The flowers are purple colored, single, 1.5.2 inch long and covered with small hairy structures. The fruits are oval to round shape, 1 inch long. The seeds are triangular and flat.

Properties:
Rasa (Taste) – Tikta (Bitter)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf, Root

Dosage-
Powder- 1 to 3 g

Decoction- 50 to 100 ml
Fresh juice- 5 to 10 ml

Chemical composition:
Leaves and fruit contain ceryl alcohol, aristolochic acid and beta-sitosterol. Roots contain aristolochic and Potassium chloride nitrates. It also contains bitter principle glucoside in nature named isoaristolochic and Allanton 0.05% alkaloid Aristoloclen, essential oil containing carbonyl compound and a small amount of an oil with above of Isovanilin.

Aristolochia bracteata

 

Uses of Kitamari:

  • The paste of the leaf of Kitamari is applied over the wounds for helping in quick healing.
  • The decoction of the leaf of Aristolochia bracteolate is consumed in a dose of 50 ml to treat dysmenorrhea and difficulty in labor.
  • The decoction of the bark or whole plant is taken in a dose of about 40 ml to treat intestinal worm.
  • The paste of the leaf of Kitamari is applied over eczema for its treatment.
  • The powder of the seed of Aristolochia bracteolate is given with powder of black pepper to treat fever.
  • The paste of the root of Aristolochia bracteolate is applied over the area over localized swelling for its treatment.

Adverse effects: No known adverse effect is known or reported after the use Kitamari.

Research articles related to Aristolochia bracteolata:
Anti- microbial activity: The present study describes the antimicrobial activity of the acetone, ethanol and petroleum ether extracts of the leaves, stem and root of Aristolochia bracteolata Lam. using agar diffusion method against human pathogenic bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Bacillus aureus and Klebsiella pneumoniae. In the present research, all the extracts were found to be effective against four human bacterial species, E.coli, P.aeruginosa, K.pneumoniae and B.aureus sensitive to all the plant extracts.

Anti- bacterial and anti- fungal action: The phytochemical analysis of both the aqueous and methanolic extracts of the medicinal plant Aristolochia bracteolata Retz. and their antibacterial and antifungal activities against six pathogenic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Leuconostoc lactis, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi as well as four fungus namely Aspergillus niger, Aspergillus flavus, Rhizopus indicus and Mucor indicus were investigated. Antibacterial potentiality of aqueous and methanol solvent extract of mature leaves of A. bracteata was evaluated against the bacteria, highest antibacterial activity was observed against Streptococcus pyogenes (42 mm) and followed by Pseudomonas aeruginosa (38 mm) in methanol extract. But in the case of antifungal activity the maximum inhibition zone found against Rhizopus indicus (18) in methanol extract. There is no activity antibacterial and antifungal activity found in the aqueous extract.

Anti- inflammatory action: Anti- inflammatory action with the ethanol extract of the leaves of the plant Aristolochia bracteolata showed significant action in wistar rats.

 


Ishwari (Aristolochia indica) Medicinal uses and pharmacology

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Ishwari (Aristolochia indica) Medicinal uses and pharmacology

Aristolochia indica

 

 

 

Ishwari- Aristolochia indica is an ayurvedic herb useful for the treatment of localized swelling, cases of poisoning by inducing vomiting, skin diseases, cough and painful periods.  

Latin name- Aristolochia indica Linn.
Family- Aristolochiaceae

Names in different languages:
Siddha name: Adagam

Hindi name: Isharmul, Isarmul, Hooka bel
English name: Indian Birthwort, Snake root
Arabic name: Zaravande
Assamese name: Jarvande
Bengali name: Ishormul, Isheri
Gujarati name: Sapsan, Ruhimula, Iswarimool
Kannada name: Ishwari Beru, ToppaluKonkani name: Sapsikaddul
Marathi name: Sapasan
Malayalam name: Garudakkoti, Garudakkodi, Karaleyan, Cheriya arayan
Oriya name: Gopikaron
Sinhalese name: Sapsanda
Tamil name: Adagam, Isadesatti, Isura, Isuramuli, lyavari, Karudakkodi, Kirttikkodi, Neya, Perumarindu, Perumaruntu, Perunkilangu, Sarsugadi, Talaichuruli
Telugu name: Ishveraveru, Esvaraveru
Urdu name: Zarawand Hindi

Aristolochia indica

 

 

Sanskrit Synonyms:
Nakuli, Ahigandha, Arkamula, Garuda, Ishvara, Ishvari, Nakuleshtha, Nakuli, Sunanda, Rudrajata, Ishwari, Naakuli, Arkmuula, Gandhnakuli, Nagadamani

Morphology of Aristlochia indica:
Aristolochia indica is a glabrous, shrubby or herbaceous perennial plant with woody root stock and long, slender, grooved, glabrous branches. It is found mostly in the Himalayan belt near Nepal, South India and Bengal up to an altitude of 3000 feet. The stem part of the climber is woody and thin. The leaves are 2-4 inch in length and 1-2 inch wide, variable, fiddle shaped to linear. It is glabrous with a slightly undulate margin. The flowers are 1-1.5 inch in length, found in small clusters and they appear like hood of the cobra. They are purple colour inside and pale green in the outer rim. They bloom in the rainy season. The fruits are round and are found in the month of November to March. The seeds are triangular and flat. The roots of the plant are long and cylindrical with little bends.  The outer side is brownish with white colour inside. They are bitter in taste and have camphor like odour.

Properties:
Rasa (Taste) – Katu (Pungent), Tikta (Bitter), Kashaya (Astringent)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature)
Vipaka – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Root, Leaf
Dosage-
Root powder- 1 to 3 g

Leaf juice- 5 to 10 ml

Chemical composition:
Aristolochia sp. contains aristolochic acids and aristolactams. The plant Ishwari, especially roots, contains Aristochine, Aristolochene, Ishwaronw, Aristolochine acid, Ishwarane, Cephaeradiones and Aritistolindiquinone.

 

Aristolochia-indica-1.jpg

 

Uses of Ishwari:

  • The powdered root of Ishwari is given with honey in a dose of 3 g fordropsy, leukoderma, tonsillitis and chronic dyspepsia.
  • One pinch of root powder of Aristolochia indica is taken with warm water to treat fever, indigestion, and digestive disorders.
  • The paste prepared from the leaf of the plant is applied over the joints affected with pain and swelling.
  • The paste of the fresh leaf is applied over the forehead with turmeric powder to reduce headache.
  • The powder of the seed of Ishwari is mixed with warm water and applied over joints to reduce pain and inflammation.
  • For leucoderma, skin diseases, wounds and swelling the paste of leaves is applied topically on affected areas.
  • In patients suffering from cough, the juice of the leaf of Aristolochia indica is given in a dose of 5-6 ml to induce vomiting and remove the excessive kapha dosha.
  • Cold infusion from the root of the plant is given in a dose of 40-50 ml to treat dysmenorrhea and difficulty in labor.
  • Decoction of the root of Aristolochia indica is given in a dose of 30 ml to treat retention of urine.
  • The fresh juice of the leaf is administered in a dose of 5-10 ml to induce vomiting in cases of poisoning from scorpion bite and snake bite.

 

Adverse effects: Excess use of the root and leaf of Ishwari can cause nausea, vomiting and abdominal cramps. Hence the herb should be used with extreme care.

This plant contains aristolochic acid, a carcinogen also found in various Aristolochia and Asarum plants, both in the Aristolochiaceae family of plants. Aristolochic acid is composed of an about 1:1 mixture of two forms, aristolochic acid I and aristolochic acid II.

In addition to its carcinogenicity, aristolochic acid is also highly nephrotoxic and may be a causative agent in Balkan nephropathy. However, despite these well-documented dangers, aristolochic acid still is present sometimes in herbal remedies (such as for weight loss), primarily because of substitution of innocuous herbs with Aristolochia species. The alcoholic extract is more toxic than the water extrac

 

Ayurvedic medicines containing Ishwari:
Gorochanadi vati: Gorochanadi Gulika is a tablet, used in Ayurvedic treatment of fever, pneumonia, cough, cold, bronchitis, asthma, diseases of throat, tonsillitis, chronic fever.

Pukaghanda: It is an Ayurvedic medicine, in granules form. It is used in Ayurvedic treatment of vomitting, abdominal pain, dyspepsia, gastritis, bleeding diseases, anemia and constipation.

Dandrux oil: It is a proprietary Ayurvedic hair oil, used in the treatment of chronic dandruff.

Mathala rasayana: Mathala Rasayanam is an Ayurvedic medicine in lehya form, used in digestive and respiratory diseases.

Mahavishagarbha taila: Maha Vishagarbha Taila is a herbal oil used in Ayurvedic treatment of neuro-muscular conditions, sciatica, tetanus, stiffness and tightness in back and limbs, Tinnitis and lack of tactile sensation. It is used for external application.

 

Aristolochia-indica

 

Research articles related to Aristlochia indica:


Anti- microbial activity: The present study was designated to evaluate the antimicrobial activities of ethanolic extract of Aristolachia indica L. The antimicrobial activities of the extract against 12 strains belong to bacterial and fungi species were tested by using agar diffusion method. The results showed that ethanolic extract of Aristolachia indica had moderately significant antibacterial and significant antifungal activity. It inhibited the growth of both bacterial and fungal species dose dependently. The inhibition of growth was highest at 100mg/ml as compared to the controls. Ethanolic extract showed stronger antimicrobial activity against the fungi than that of the bacteria.

Nephro- protective action: The aim of the study was to determine the protective effect of Aristolochia indica leaf extract on Gentamicin induced nephrotoxicity in rats using biochemical approaches. Oxidative stress is the main factor in Gentamicin (GM) induced nephrotoxicity. Nephrotoxicity was assessed by measuring the abnormal levels of serum creatinine, urea and sodium and decreased level of protein and potassium. Treatment with Aristolochia indica leaves (500 mg/kg) significantly (p < 0.05) restored the levels of serum creatinine, urea, sodium, protein and potassium. Significantly (p < 0.05) increased the antioxidant defence enzyme levels of SOD, GPx and CAT on treatment with Aristolochia indica. The results suggest that an Aristolochia indica leaf has the potential in preventing the nephrotoxicity induced by Gentamicin.

 

The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response.

Fibrinogen and β-amyloid (Aβ) peptide independently form ordered aggregates but in combination, they form disordered structures which are resistant to fibrinolytic enzymes like plasmin and cause severity in cerebral amyloid angiopathy (CAA). A novel enzyme of 31.3 kDa has been isolated from the root of the medicinal plant Aristolochia indica that showed fibrinolytic as well as fibrin-Aβ co-aggregate destabilizing properties. This enzyme is functionally distinct from plasmin. Thrombolytic action of the enzyme was demonstrated in rat model. The potency of the plant enzyme in degrading fibrin and fibrin-plasma protein (Aβ, human serum albumin, lysozyme, transthyretin and fibronectin) co-aggregates was demonstrated by atomic force microscopy, scanning electron microscopy and confocal microscopy that showed better potency of the plant enzyme as compared to plasmin. Moreover, the plant enzyme inhibited localization of the co-aggregate inside SH-SY5Y human neuroblastoma cells and also co-aggregate induced cytotoxicity. Plasmin was inefficient in this respect. In the background of limited options for fragmentation of these co-aggregates, the plant enzyme may appear as a potential proteolytic enzyme.

 

Classical categorization:
Bhavaprakasha- Haritakyadi varga

Raja Nighantu- Mulakadi varga

 

Rhubarb – Rheum emodi Medicinal uses, Adverse effects,Research & pharmacology

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Rhubarb – Rheum emodi Medicinal uses,Research and pharmacology

 

 

Pita mula- Rheum emodi is an ayurvedic herb mentioned for the treatment of low digestion, constipation, dysmenorrhea, jaundice etc. It is also known as Rhubarb or Revand chini. 

 

 

Latin name- Rhum emodi Wall.
Family- Polygonaceae

Names in different languages:
English name: Indian rhubarb or Himalayan rhubarb
Hindi name: Dolu, Revandchini.
Afghanistani name – chukri, Rawash
Arabic name –  Revanch chini, Rawind
Bengali name – Revandchini
Bombay name – Ladakirevand chini
Canarese name – Naturevalchini
Deccan name – Nahirevandchina
French name : Hubarb de parse
Gujarathi name: Revandchini, Gamni,
Gujarathi :revandchini.
Himachal Pradesh : Ladu, chuchi.
Kamaun: Archu
Kannada name: Revalchini
Ladak : Lachu
Marathi name : Mulkarcvand chini, Revanchini.
Nepalese name: Padamachal
Persian name : Bikrewas, Revandchini.
Punjab : Atsu , Chotial, Chuchi, Pambash, Chutial, Khabium, Lachu, Rewand chini.
Spiti : Lachu.
Tamil name : Variyattu, Natturevandchini
Telugu : Nattupampuch, Nattureval chini
Urdu : Rewand chini

Sanskrit synonyms:
Amlaparni- The leaves are sour in taste

Pitamulika- The roots are yellow in color
Grandhika, Gandhini- The plant has a dominant odor
Swedachini, Revadhika, Hrithdhatri, Kankushta

 

Morphology of Rheum emodi:
Rhubarb is a stout herb 1.5 – 3.0 m in height, distributed in the Himalayas from Kashmir to Sikkim at altitude of 3,300 m to 5,200 m. It is also cultivated in Assam for its leaves consumed as vegetable. The stem is hard, green with brownish streaks. The flowers are 2-3 foot long and purple to reddish colored seen in the month of July to August. The fruits are about 1-2 cm long, purple colored and seen in the month of September to October. The root of the plant is thick, strong and yellow in color. The roots are dried and sold. There are three main types of rhubarbs—Chinese, Indian or Himalayan, and Rhapontic.

 

Revandchini – medicinal properties:
Rasa (Taste) – Katu (Pungent), Tikta (Bitter)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphapiyta shamaka (reduces vitiated kapha and pitta dosha)

Part used- Underground stem, Root
Dosage- 0.2 g to 1 g

Chemical composition of Rheum emodi:
The root gave emodin, emodin-monomethyl ether, chrysophanol, aloemodin, rhein. These occur free and as quinone, anthrone or dianthroneglycosides. The astringent principle consists of gallic acid together with small amounts of tannin. The drug also contain cinnamic and rheinolic acids, volatile oil, starch and calcium oxalate. Two major glycosidic active principles, sennoside A and B, are present along with free anthraquinones. Rhubarb also contains rhein acids and calcium oxalate. Rhubarb yields to alcohol about 40 % of extractives.

Habitat:
Himalayas from Kashmir to Sikkim

Assam
Cultivated in China, Tibet, India, Germany and other European countries.

गन्धिनी पीतमूली च बल्या सा मृदुरेचनी ।
हन्त्यजीर्णमतिसारं वह्रिमान्ह्यमरोचकम् ॥ Ayurveda Vijnana

Uses of Pitamuli:

  • The powdered root of Indian Rhubarb is sprinkled over wound for wound healing.
  • The leaf stalk is used as fresh salad and vegetable.
  • The powder of the stem and root is used in a dose of 0.5 g with hot water to relieve constipation.
  • Cold infusion of the leaf of Pitamuli is given in a dose of 25 ml to treat dysmenorrhea and retention of urine.
  • The powder of the root is used as dental powder for cleaning the teeth and treating gingivitis.
  • The powder of the root of Rheum emodi is given in a dose of 1 g to treat hepatomegaly and jaundice.
  • The fresh leaf of the plant improves the appetite and increases the digestive capacity and hence can be used as raw salad.
  • The powder of the root of Pitamuli is given in a dose of 0.5 g with honey to treat cough and rhinitis.

Adverse effects: Excessive use of the roots of Pitamuli can cause increased peristaltic movement leading to diarrhea and cramps. Hence care should be taken during its use.

Ayurvedic medicines with Rubarb as ingredient:
Chiniumco tablet: This is a proprietary Ayurvedic medicine used in the treatment of profuse bleeding from nose, intestine, piles, uterus etc.

Arjin tablet:  This is a proprietary Ayurvedic medicine used in the management of hypertension.

Bleminor cream: It is a proprietary Ayurvedic medicine. Bleminor’s anti-inflammatory property is beneficial in preventing hyper-pigmentation due to recurrent inflammation. It also aids in correcting skin discoloration resulting from injury.

Kankayanvati: This is a medicine in tablet form useful to treat intestinal worms, piles, bloating of the abdomen.

Panchamla taila: Panchamla Thailam is an Ayurvedic oil used externally for the treatment of ascites, rheumatoid arthritis and joint pain.

Research articles related to Rheum emodi:
Anti- oxidant activity: This study aims to investigate antioxidant power of stilbenoids from R. emodi and then explore the material basis for its antioxidant potential. The most abundant stilbenoid piceatannol-4′-O-β-D-glucopyranoside (PICG) and its aglycon piceatannol (PICE) were isolated from R. emodi rhizome. Taking into account the rapid in vivo metabolic transformation of PICG into PICE it can be inferred that the most abundant stilbenoid PICG may be an important constituent responsible for the antioxidant potential of R. emodi and promising to be developed as an antioxidant agent for supplementary or therapeutic use.

Anti- microbial activity: Powders of Smukorossi and Remodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited H pylori at very low concentrations. In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations (10 μg/mL) for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi (2.5 mg/mL) and R. emodi (3.0 mg/mL) given orally for seven days.

Anti- fungal activity: Podophyllum hexandrum and Rheum emodi were investigated for their antimicrobial properties against pure cultures of clinical isolates of Aspergillus niger ATCC 1197 and Candida albicans ATCC 10231. The results of the antimicrobial assay of the methanolic extracts of both the plant extracts indicated that the plants exhibited antimicrobial activity against the tested microorganisms at four different concentrations of 25mg/ml, 50mg/ml, 75mg/ml and 100mg/ml.

Hepato -protective action: The protective potential of the total Anthraquinone glycoside fraction of Rheum emodi was determined by evaluating Aminotransferase activity, mitochondrial membrane potential, calcium-induced liver MPT (Mitochondrial permeability transition) and VDAC expression. Pretreatment with a total Anthraquinone glycoside fraction of Rheum emodi showed significant preservation of mitochondrial membrane potential as compared to CCl4 control demonstrating the mitochondrial protection. In addition, pretreatment with TAGF Rheum emodi at various concentrations exerted a dose-dependent effect against sensitivity to mitochondrial swelling induced by calcium.

Classical categorization:
Bhavaprakasha- Dhatwadi varga

Nighantu Adarsha- Nagapushpadi varga

Scientific classification
Kingdom: Plantae
Order: Caryophyllales
Family: Polygonaceae
Genus: Rheum
Species: R. emodi

Common Adulterants:
Rheum Webbianum Royle.

Rheum Moorcroftianum Royle.
Rheum Spiciforma Royle.
Rheum Nobile Hook.

 

Chukra Rumex vesicarius Medicinal uses, Adverse effects,Research & pharmacology

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Chukra Rumex vesicarius Medicinal uses, Adverse effects,Research & pharmacology

 

Chukra- Rumex vesicarius is an Ayurvedic herb used for the treatment of constipation, diseases of the liver, scorpion bite, snake bite, piles and vomiting.

Latin name- Rumex vesicarius Linn.
Family- Polygonaceae

Names in different languages:
English name – Bladder dock, Sorrel, Bubble dock, Rosy Dock,

Hindi  name  – Ambari, Chuka, Chukekasak
Kannada name- Chukka
Arabic name – Hamaz, Humarbostani, Humbijit
Assamese name – Sukhasag
Bengali name – Chak, Chuk, Chukapalang
Bombay         – Chuka
Burmese name – Kalakhenbour
Deccan name – Ambari, Chukka
Malayalam name – Chokkancheera
Persian name            – Tursak, Turshah, Turshunuk
Punjabi name – Kattamitha, Khatbiri, Saluni
Tamil  name  – Chukka
Telugu name   – Chukka kura

Synonyms:
Amla, Amlabhedaka, Sinchamla, Shuktika, Sahasravedhi, Amlantaki, Rajamla, Rasamla, Vetamla, Viramla- All these names indicate the sour nature of the plant

Bhedana, Gulmaha, Beeta, Shukta, Chanda,

Morphology of Rumex vesicarius:
Chukra is a plant growing to a height of 15-3 cm. It is found in most parts of India in a state of cultivation or as a garden escape. It occurs in western Punjab, salt range and Trans-Indus hills. It grows especially in hilly areas and Himalayan zone.

Medicinal properties of Bladder dock:
Rasa (Taste) – Amla (Sour), Madhura (Sweet)

Guna (Qualities) – Laghu (Light for digestion)
Vipaka – Amla (Undergoes sour taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Vata shamaka (reduces vata dosha), Kapha pitta vardaka (Increases kapha and pitta dosha)

Part used- Whole plant, Seed

Dosage-
Fresh juice- 10 to 20 ml

Powder- 2 to 3 g

Chemical composition:
Fresh and green herb contains 92% water content dried plant contain either extract 4.62%, albuminoid 16.27%, carbohydrate 57.86%, woody part 10.50% and alkaline 10.75%. Root contains Rumicin and lapathin. It also contains an anthraquinone glucoside, aminoacids, vitamins, cystine, glutamic acid, histidine etc.

Uses of Chukra:

  • The paste of the leaf of Rumex vesicarius is kept in the gums and tooth affected with dental caries to relive pain and inflammation.
  • The paste of the leaf of Chukra is applied over the area affected with scorpion bite to relive pain and inflammation.
  • The seeds of Rumex vesicarius is roasted and powdered and is taken internally to treat scorpion bite and diarrhea.
  • The decoction of the plant is given in a dose of 30 ml with supernatant layer of curd and juice of pomegranate to treat diarrhea.
  • The juice of the leaves of Chukra is slightly warmed and installed into the ears to treat earache.
  • The decoction of the whole plant is given in a dose of 50 ml to treat hepatomegaly and piles.
  • Fresh juice of the leaf of Chukra is given in a dose of 10 ml to treat vomiting.
  • Rice gruel boiled with Chukra and nagakesara (Mesua ferrea) is given to treat bleeding piles and diarrhea associated with blood.

Uses of Chukra as per Ayurveda: 
Pittakrut – Increases Pitta Dosha
Rakrakrut – can increase bleading disorders
Vatashamana – Balances Vata Dosha
Bastishuddhikara – cleanses and detoxifies kidneys and bladder
Deepana – improves digestion strength
Pachana – Digestive, relieves Ama Dosha
Sara – induces mobility, causes diarrhea, purgation, relieves constipation

Indicated in – 
Shoola – abdominal colic pain
Gulma – Tumors of the abdomen
Vibandha – constipation
Amavata – rheumatoid arthritis
Vami – vomiting
Trushna – excessive thirst
Asyavairasya – bad berath
Hrutpeeda – Cardiac pain
Vahnimandya – low digestion strength

Pharmacological action:
Laxative, stomachic. It is useful in tumours, constipation, alcoholism, diseases of spleen, hiccough, flatulence, asthma, bronchitis, dyspepsia, vomiting & piles.

Adverse effects: There are no known adverse effects of the herb Chukra
It is best to avoid this in high Pitta disorders such as diseases associated with excess bleeding.
Because it acts as laxative, it is not suitable for people with diarrhea.

Ayurvedic medicines containing Chukra:
Marma gulika: Marma Gulika is a tablet, used in Ayurvedic treatment of diseases of Marma places – vital organs, means, diseases related to heart, brain, urinary system etc. It is also used to treat external injury to vital organs of the body.

Research articles related to Rumex vesicarius:
Hepato protective action: To evaluate the hepatoprotective potential and in vitro cytotoxicity studies of whole plant methanol extract of Rumex vesicarius L. Methanol extract at a dose of 100 mg/kg bw and 200 mg/kg bw were assessed for its hepato- protective potential against CCl4-induced hepatotoxicity by monitoring activity levels of SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamic pyruvic transaminase), ALP (Alkaline phosphatase), TP (Total protein), TB (Total bilirubin) and SOD (Superoxide dismutase), CAT (Catalase), MDA (Malondialdehyde). Pretreatment of animals with whole plant methanol extracts of Rumex vesicarius L. significantly reduced the liver damage and the symptoms of liver injury by restoration of architecture of liver. The biochemical parameters in serum also improved in treated groups compared to the control and standard (silymarin) groups. Histo pathological investigation further corroborated these biochemical observations.

Anti- bacterial action:The main aim of this research work is to evaluate antibacterial and antioxidant activities of different plant parts of Rumex vesicarius L. The pattern of inhibition, activity index and proportion  index  showed  highly  significant  variations  according  to  variations  of  solvents  used  for  extraction. Ether  extract  of  roots  was  found  to  be  the  most  effective  against  Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus  and  Streptococcus pyogenes (inhibition zones=26.500, 22.000, 41.5000 and 21.500 mm respectively), methanol extract of roots was found to be the most  effective  against  Streptococcus pneumoniae  (inhibition zone  =18.000 mm) and ethanol extract  of  flowers was  found  to  be  most effective  one  against Escherichia coli (inhibition zone =15.875 mm).

Anti- diabetic activity: The main objective of this work is to evaluate the in vivo anti diabetic activity of ethanolic extract of Rumex vesicarius in the streptozotocin induced diabetic rats. Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes in albino rats. The statistical data indicated that the different dose of Rumex vesicarius significantly decreases the level of blood glucose in streptozotocin induced rats. This result indicated that Rumex vesicarius can protect pancreatic βcells from streptozotocin induced damage which is confirmed by the results of histo pathological examination of pancreas.

Anti- cancer action: The goal of the current study was to explore the potent role of Rumex vesicarius extract against Hepato Cellular Carcinoma (HCC) induced in rats. The results of the current study showed that the treatment of the HCC group with R. vesicarius extract reversed the significant increase in liver enzymes activity, CEA, AFP, AFU, glypican 3, golgi 73 and VEGF levels in serum as compared to HCC-untreated counterparts. In addition, the favorable impact of R. vesicarius treatment was evidenced by the marked improvement in the histo pathological features of the liver of the treated group.

Classical categorization:
Bhavaprakasha Nighantu – Shakha varga & Hareethakyadi varga

Priya Nighantu – Hareethakyadi varga
Nighantu Adarsha – Chukrikadi varga
Kaiyadeva Nighantu – Aushadha varga
Dhanvantari Nighantu – Amradi Varga

Scientific classification

Kingdom: Plantae
Order: Caryophyllales
Family: Polygonaceae
Genus: Rumex L.

Textual reference:
Susruta quoted chukra, but not cukrika and chukrika. In caraka samhita chikitsa 24/150 [ C.S.Ci 24/ 150] and A.H. Ci. 7/31 both cukrika and chukrika are mentioned together. They may be Rumex vesicarius linn and R.acetosella linn respectively.

 

Gorakshaganja (Aerva lanata) Medicinal uses, Adverse effects,Research & pharmacology

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Gorakshaganja (Aerva lanata) Medicinal uses, Adverse effects,Research & Pharmacology

 

Gorakshaganja- Aerva lanata is a plant mentioned in Ayurveda for the treatment of renal calculi, retention of urine, cough and sore throat. The plant has promise on anti HIV activity. 

Latin name- Aerva lanata Juss.
Family- Amaranthaceae

Names in different languages:
Hindi name: Gorakhbuti or Kapuri jadi, Gorakshaganja, Gorkhabundi, Kapurijidi, chaya.
English name: Mountain knot grass
Bengali name: Chaya
Kannada name: Bilesuli, Bilihindi soppu
Malayalam name: Cherula, Cerula, Ceruvuta
Marathi name: Kapuri-madhura, Kapurmadhura, Kumrapindi , Kapurphuti
Punjabi name: Bui-kaltan (flowers as sold in bazaars)
Tamil name: Sirru -pulay –vayr, Cerupulai, Poolai
Telugu name: Pindi-kura, Pindi-chettu, Pindiuttu, Kondapindichettu

Gujarathi name – Bur, Kapurimadhuri
Assamese name – Bameha
Spanish name- Sanguinaria de cuba
Deccan name – Khul-Khul
Mundari- Cauliara
Sind- Bui
Trans- Indus-Azmei
Punjab- Baikallau

 

Sanskrit Synonym:
Pashanabheda- That which destroys the stones

Morphology of Aerva lanata
Aerva lanata is a common weed which grows wild everywhere in the plains of India. The root has a camphor-like aroma. The flowers are seen as clusters and are pale green in color. The dried flowers which look like soft spikes, are sold under the commercial names as Buikallan or Boor. The fruits and flowers are seen in the month of November to January. This herb is taken as a variety of Pashanabheda in South India.

Medicinal Properties of Gorakshaganja:
Rasa (Taste) – Tikta (Bitter), Kashaya (Astringent)

Guna (Qualities) – Laghu (Light for digestion), Teekshna (Strong)
Vipaka – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Prabhava (Special action)- Ashmari bhedana (Destroys the stones)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Root
Dosage- 50 to 100 ml of decoction

Habitat:
Goraksha ganja (Aerva lanata) grows throughout India in the plains upto 1000mts on the hills,Ceylon, Arabia,tropical Africa, Java, Philippines.

Chemical composition of Aerva lanata:
The plant contains palmitic acid, beta-sitosterol and alpha-amyrin. The flowering and fruiting parts contained hemicellulose, starch an acid- soluble polysaccharide & H2o soluble polysaccharides, monosaccharide contents of polysaccharides determined.

गोरक्षगञ्जा तुरा सतित्ता, लघ्वी च तीक्ष्णा परमोष्णवीर्या।
कफार्त्ति मूत्रविरेचनीया, प्रभावतोऽप्यश्मरिनाशनी स्यात् ॥      ( द्र. गु. वि)

Uses of Gorakshaganja:

  • The decoction of the root of Aerva lanata is given in a dose of 50-60 ml to treat renal calculi and retention of urine.

  • Cold infusion of the whole plant is given in a dose of 30-40 ml to treat cough and sore throat.

  • The dried leaf and flowers of Gorakshaganja are burnt and the smoke coming from it is used for inhalation to treat asthma and chronic cough.

  • The paste of the plant is applied over forehead to treat headache.

  • The paste of the root is made into decoction and given in a dose of 30 ml to treat gonorrhea.

  • The cold infusion of the root of Aerva lanata is given to pregnant women as tonic to improve the body strength.

Pharmacological actions
Anthelmintic – useful in intestinal worm infestation

demulcent & lithasis.
useful in cough, sore  throat, indigestion, wounds & as specific for diabetes.
Decoction is efficacious diuretic & is useful in catarrh of bladders. It is said to cure diarrhea, cholera & dysentery.
Flowers are lithotryptic.

Adverse effects: No adverse effects are reported after the normal use of this herb.

Ayurvedic medicines containing Gorakshaganja:
Marma gulika: Marma Gulika is a tablet, used in Ayurvedic treatment of diseases of Marma places – vital organs, means, diseases related to heart, brain, urinary system etc. It is also used to treat external injury to vital organs of the body.

Ureaze tablet: It is a proprietary Ayurvedic medicine useful in the treatment of urinary tract infection and also acts like a diuretic.

Virataradi kashaya: It is a decoction used in the treatment of renal calculi, retention of urine and vata predominant diseases.

Research articles related to Aerva lanata:
Anti- microbial study: The antioxidant potential of Aerva lanata was investigated in this study. The plant exhibited the most potent radical scavenging activity at a maximum concentration 2.5mg/ml. Natural antioxidants such as Flavonoid, Total phenols, Tannin, Carotenoids and Lycopene were evaluated and also the antioxidant activity against DPPH, Super oxide anion, Hydroxyl radical, Nitric oxide radical, Hydrogen peroxide radical, Total antioxidant capacity assay and anti-lipid peroxidation activity were evaluated. Aerva lanata showed high anti lipid peroxidation against TBA. Strong antioxidant activity showed in aqueous ethanol extracts than water and ethanol extracts, and similar to standards ascorbic acid and BHT.

Anti- HIV activity: The aim of the present study was to evaluate the anti-HIV activity and cytotoxic effects of Aerva lanata root extracts. All extracts exhibited the most notable activity and the chloroform extract of Aerva lanata showing highest (91.0%) HIV-RT inhibition at 2mg/ml concentration, hexane, ethyl acetate and acetone extractions showed highest inhibition of HIV-RT at 2 mg/ml concentration (86.9, 85.2 and 77.5 respectively). While control drug (AZT) showing 91.7% at 2mg/ml concentration. IC50 value of all extracts determined below 40mg/ml.

Anti- urolithiatic activity: . In this study aqueous, chloroform, benzene extracts of Aerva lanata (L.) and standard for dissolving kidney stones- calcium oxalate by an in-vitro model. To check their potential to dissolve experimentally prepared kidney stones- calcium oxalate by an in-vitro model for Aerva lanata (L.) and cystone as a standard compound collected from market. Phenolic compound isolated from the benzene and aqueous, flavanoids and steroids from aqueous fraction of the leaf. Aqueous fractions showed highest dissolution of stones as compare to others.

Anti- diabetic action: This study was undertaken to evaluate the effect of an alcoholic extract of A. lanata (AAL) on blood glucose and other biochemical parameters in alloxan-induced diabetic rats. AAL was found to reduce the increase of blood sugar in alloxan-induced diabetic rats (42% at 375 mg/kg and 48% at 500 mg/kg body weight). Chronic administration of AAL significantly (P<0.001) reduced the blood sugar of alloxan induced diabetic rats for 2 weeks. Also the extract prevented a decrease in body weight and reduced the increased lipid peroxides in alloxan induced diabetic rats.

Scientific classification
Kingdom: Plantae

Order: Caryophyllales
Family: Amaranthaceae
Subfamily: Amaranthoideae
Genus: Aerva
Species: A. lanata

 

Ashwagola- Isabgol (Plantago ovata) Medicinal uses, Adverse effects,Research & Pharmacology

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Ashwagola- Isabgol (Plantago ovata): Medicinal uses, Adverse effects,Research & Pharmacology

 

Ashwagola – Plantago ovata, more commonly known as Isabgol, is an Ayurvedic herb used for the treatment of constipation, distention of abdomen, herpes, piles. 

Latin name- Plantago ovata Forsk.
Family- Plantaginaceae

Scientific classification of Isabgula
Kingdom: Plantae
Order: Lamiales
Family: Plantaginaceae
Genus: Plantago
Species: P. ovata

 

Psyllium husk Names in different languages:
Hindi name- Isabgol, Ashwagol

English name- Spogel seeds, Psyllium, Isphagul
Arabic name- Bajkathuna
Gujarathi name- Umatho jeeru
Kannada name- Isapgolu
Tamil name- Isappa
Telugu name- Isapgol

Sanskrit Synonym of Aswagol:
Ashwakarna- Seeds resemble ear of horse

Ishadgol- Seeds are little round
Sheetabeeja, Ashwagol

Morphology of Plantago ovata:
Aswagol is a small bushy shrub growing to a height of 2- 3 feet all over India. It is cultivated in some parts of North West India like Rajasthan and Punjab. The leaves are 4-8 inch long. The flower stalk is oval shaped. The fruits are little oval in shape and are about 7-8 mm long. The seeds inside the fruits are of ear shaped and white in color. The seeds are mucilaginous in nature.

Isabgol medicinal properties:
Rasa (Taste) – Madhura (Sweet)

Guna (Qualities) – Snigdha (Has moisture), Guru (Heavy), Picchila (Slimy)
Vipaka – Madhura (Undergoes sweet taste after digestion)
Veerya (Potency) – Sheeta (Madhura)
Karma (Actions) – Vata pitta shamaka (reduces vitiated vata and pitta dosha) Some others opine that it balances down Kapha and Pitta Dosha.

Part used- Seeds, Husk of seed
Dosage- 5 to 10 g

Chemical constituents of Plantago ovata:
The seed contains amino acids including valine, alanine, glutamic acid, glycine, cystine, lysine, leucine and tyrosine; and a mucilage consisting of a mixture of polysaccharides composed mainly of xylose, arabinose and galacturonicacid; rhamnoseandgalactose are also present. The seeds also gave aucubin, the antibacterial principle. The seed coat contains fatty acids mainlylinoleic, oleic and palmitic acids in decreasing concentrations.

ईषद् गोलं परं वृष्यं मधुरं ग्राहि शीतलम् ।
पिच्छिलं तुवरं किञ्चित् वातकृत् कफपित्तहत्॥
रक्तातिसारास्रपित्तं नाशयेदिति कीर्तितम् ॥         ( वैह्यामृतम् )

Uses of Ashwagol:

  • The seed husk of Ashwagol is soaked in water for a couple of hours and later it is consumed to treat distention of abdomen, constipation and flatulence.
  • The seed of Isabgol is made into powder and the powder is consumed in a dose of 3 to 5 g to treat burning sensation, excessive thirst in the body and fever.
  • The seeds are fried in ghee and consumed to treat Irritable bowel syndrome.
  • Seeds of Isabgol are made into paste and applied externally in cases of Herpes, Localized swelling with burning sensation, area affected with pustules.
  • Cold infusion of the seeds of Isabgol is consumed in a dose of 30-40 ml to treat retention of urine.

Adverse effects: Excess use of the seeds or husk of Isabgol may cause severe purgation, leading to dehydration.

 

Ayurvedic medicines containing Psyllium husk:
Constiwin capsule: It is a proprietary Ayurvedic medicine. It is a laxative used to treat constipation, piles, flatulence and fistula in ano.

Laxoherb powder: It is a proprietary Ayurvedic medicine. It is used to treat hyperacidity, piles, fissures, indigestion, flatulence and heart burn.

Golax powder: It is a proprietary Ayurvedic medicine. It is used in the treatment of constipation, incomplete bowel evacuation, hemorrhoids, Irritable bowel syndrome and diverticulitis.

Laxogold capsule: It is a proprietary Ayurvedic medicine useful to treat constipation.

Research articles related to Plantago ovata:
Anti-tumor action: Plantago major (seeds and leaves) and Cyamopsis tetragonoloba (guar beans were analyzed for general chemical components including, fatty acids and amino acids. Plantago leaves extracts exhibited higher antioxidant activity than plantago seeds and guar beans extracts. The ethanolic, hot and cold extracts of plant induced anticancer activity with various degrees. Ethanolic extract of P. major leaves possessed the greatest effect on tumor cell growth (Dead 74%) followed by hot water extract of P. major leaves (Dead 54.6%).

Protection of Intestinal mucosa: To evaluate the anti-ulcerogenic effect on duodenal mucosa of the soluble fiber Plantago ovata husk, low-dose acetylsalicylic acid (10 mg/kg) was given orally to animals once daily for 14 or 28 days with and without Plantago ovata husk (100 mg/kg). 24 h after final dosing duodenal samples were removed for anatomopathological evaluation. Villi were examined by both light and scanning electron microscopy. Findings suggest that Plantago ovata husk may protect intestinal mucosa probably by limiting acetylsalicylic acid penetration into epithelial cells, although further studies are needed to confirm the same effect in other experimental models of induced mucosal damage and to elucidate the mechanisms of fiber protection.

 

Chatraka-Mushrooms (Agaricus campestris): Medicinal uses, Adverse effects,Research & Pharmacology

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Chatraka-Mushrooms (Agaricus campestris): Medicinal uses, Adverse effects,Research & Pharmacology

 

Mushroom Agaricus campestris is mentioned in Ayurveda for the treatment of fatigue, low sperm count. improving the sperm count. It is a good source of proteins, Vitamin B, K, C and D. 

Latin name- Agaricus campestris Linn.
Family- Agaricaceae
Synonyms: Psalliota campestris

Classical categorization:
Charaka Samhita –  Shaka varga

Bhela Samhita – Shaka varg
Bhavaprakasha Nighantu – Shaka varga, Samsvedaja Shaka
Adarsha Nighantu – Bhuchhatrakadi varga
Kaiyyadeva Nighantu – Aushada varga
Madana Pala Nighantu – Shaka varga
Dravya Guna Vijnaana – Samsvedaja Shaka varga
Raja Nighantu – Shalmalyadi Varga

Scientific classification
Kingdom: Fungi
Division: Basidiomycota
Class: Agaricomycetes
Order: Agaricales
Family: Agaricaceae
Genus: Agaricus
Species: A. campestris

Synonym:
Bhumi sphota, Prithvi sphota- Emerges from the earth

Shilindra- Emerges from the stones
Kutumbaka – appears in bunches
Bhumi chatra, Bhu Chatra- Umbrella shaped structure emerging from earth
Sarpa Chatra, Bhumi kanda, Malatruna, Sumali, Bhukanda, Prithvi kanda, Rohisha,

Reference of Mushroom in Ayurveda:
Bhela Samhitha Sutrasthana 28th chapter under shaka varga 24-26th shloka. Here he has mentioned about different types like palala jata Chatraka , venu Chhatraka, gomaya chhatraka  and their respective gunas also mentioned.

In Bhela Samhitha chikitsa sthana 2nd chapter 35th shloka. In jwara chikitsa, chhatraka is mentioned in a formulation called Mahapaishashika ghrata where it is an ingredient.

Types of mushrooms as per Ayurveda:
According to Bhela samhitha:

  • Palala jatha chhatraka
  • Gomaya chhatraka
  • Venu chhatraka

According to Kaiyyadeva nighantu:

  • Krishna chhatraka
  • Sarpa chhatraka
  • Shwetha chhatraka
  • Raktha chhatraka

Some other references: White, Red, Black
Savisha chhatraka – poisonous
Nirvisha chhatraka – non poisonous

Names in different languages:
Hindi name- Khumi, Gucchi, Chhata, Chhatona, Phenchhatar, Sanpakichhatri

English name- Mushroom
Arabic name- Fitar
Assamese name- Kalphula
Bengali name- Chhata, Chhatakuda, Bhuchhati
Gujarathi name- Viladino Topp, Kagdanachhatra,Mindadnivali
Marathi name- Alambi, Alombe, Kalambe, Khumba
Kannada name- Anabe
Tamil name- Naikkodai
Telugu name- Kukkagodugu
Catalan name – Bolet decam,Bolet comu
Chamba name – Moksha,Mopsha
French name – Psalliote champetre
German name – Brachpitz,Champigon
Hausa – Namanangulu, Namankassa
Kashmir name – Manskhel
Konkani name – Kamila
Persian name – Chatrimar
Portuguese name – Cogumelo
Punjabi name – Bleophore
Spanish name – Agarico camperino
Tulu – Lambu, Kallambu

 

 

Morphology of Agaricus campestris:
Chatraka belong to fungus kingdom. It grows wildly all over India near water source or in place of good moisture content in the soil. It is also cultivated for its commercial use and used in many cuisines. Mushroom has a weak mid part and an umbrella shaped top- hence the name Chatraka. Mushrooms are available in many shape and colors like pink, brown, pale white, white, black. Only some varieties are edible and some are poisonous.  

Agaricus campestris medicinal properties:
Rasa (Taste) – Madhura (Sweet)

Guna (Qualities) – Laghu (Light) Snigdha (Contain moisture), Picchila (Slimy)
Vipaka – Madhura  (Undergoes Sweet taste after digestion)
Veerya (Potency) – Sheeta (Cold)
Karma (Actions) –Vatapitta shamaka (reduces vitiated vata and pitta dosha),
Kaphavardaka ( increase kapha dosha)

Part used- Whole fungus
Dosage- According to the requirement

Chemical constituents of Agaricus campestris:
A protein (2.75%) supplement and an excellent source of vitamins of B complex. Vitamins K, C and D are also present. Though all the amino acids are reported to be present, the concentration of tryptophane is particularly low.

Uses of Chatraka:

  • Chatraka is mainly used like vegetable in cuisines all over the world.
  • Chatraka is boiled and is consumed with ghee to improve the sperm count.
  • Mushroom is cut into small pieces and boiled in milk. This boiled milk is consumed in conditions of emaciation of the body and to improve the physical strength.
  • In conditions of hyperacidity, mushroom is taken along with ghee or sugar candy.
  • Little quantity of chatraka is taken with sugar candy in treating dry cough.
  • Mushroom is fried with ghee and consumed to improve the sexual vigor.

 

Description of mushrooms as per Ayurveda:
White variety, clean, with the colour of bamboo, cow are good to eat. They do not increase Doshas, unlike other types of mushrooms.

Other mushrooms are heavy, can cause vomiting, diarrhea, fever and Kapha disorders.

Madhura – sweet
Vrushya – Aphrodisiac, improves sexual strength
Balya – improves strength and immunity
Rooksha – dry
Hima – coolant
Guru – heavy to digest
Durjara – heavy and hard to digest
Bhedana – may cause diarrhea
Tridoshala – can increase all three Doshas

The dwarf variety is astringent, Katu Vipaka (pungent taste conversion after digestion).
Black mushroom is sweet taste and Vipaka,
White musrhoom is guru – heavy to digest
Red mushroom can increase Doshas by small extent

Adverse effects:
Some varieties of mushroom are poisonous and cause loss of sensation, diarrhea, nausea, vomiting, allergic rashes over the body, swollen lips, cramps of the muscles etc. Hence care should be taken to select the proper variety of mushroom.

 

Research articles related to Agaricus campestris:
Anti- oxidant potential: The chemical, bioactive, and antioxidant potential of twenty wild culinary mushroom species being consumed by the people of northern Himalayan regions has been evaluated for the first time in the present study. Although differences were observed in the net values of individual species all the species were found to be rich in protein and carbohydrates and low in fat. Glucose was found to be the major monosaccharide. Predominance of UFA (65–70%) over SFA (30–35%) was observed in all the species with considerable amounts of other bioactive compounds. All the species showed higher effectiveness for antioxidant capacities.

Anti- bacterial study: Antibacterial activity of methanolic and acetone extracts of Agaricus bisporus were determined in-vitro against two pathogenic bacteria Escherichia coli and Staphylococcus aureus following agar well diffusion method using different concentrations (25, 50, 75 and 100%). Methanolic and acetone extracts showed potent antibacterial activity against tested bacteria. Methanolic extract showed maximum inhibitory effect against growth of each of the test bacterium.

 

 

Country borage (Parnayavani-Plectranthus amboinicus) Medicinal uses, Adverse effects,Research & Pharmacology

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Country borage (Parnayavani-Plectranthus amboinicus) Medicinal uses, Adverse effects,Research & Pharmacology

 

Parnayavani- Plectranthus amboinicus is an plant mentioned in Ayurveda for the treatment of cough, asthma, headache, indigestion, diarrhea and intestinal worms. 

Latin name- Coleus amboinicus Lour. Plectranthus amboinicus
Family- Labiatae

Names in different languages:
Hindi name- Patta ajwayin, Amroda, Patherchur , pathercheer

English name- Country borage, Indian mint, Indian borage
Bengali name- Pathar choor, Paterchur,Amalkuchi
Gujarathi name- Ovapan
Kannada name- Dodda patre, Sambrani, Sambrani soppu
Malayalam name- Panikoorka
Marathi name- Pan ova
Tamil name- Karpooravalli, Kurpurvallai
Telugu name- Karuvacru, Suganda vallekam, Karpoorvalli
French name   :Coleus d’Afrique , Plectrianthus aromatique
German name : Cubanischer oregano,Jamaican Thymian
Japenese name Koreusu amboinikusu , Kuuban oregano
Malay name  : Daun kucing (Indonesia) , Daun Kambing(Indonesia)
Russian name : Plektrantus aromatryi
Spanish name  : Oregano
Vietnamese name:Tan day le
Mah            :Pan-ova
Gujarathi name – Ovapana
Chinese name – Zuo Shou Xiang

Synonyms:
Chornika, Karpooravalli, Sugandhi, Parnika, Himasagar, Ashmari bheda

Parnayavani is a small plant growing to a height of 1- 2 feet. The stem is fleshy but has less strength. The leaves are little oval, thick, fleshy and have hair like structure beneath with strong odor. The flowers are small, purple colored and are seen in the month of May- July. The plant is available and cultivated all over India in the temperate climate.

Properties:
Rasa (Taste) – Katu (Pungent), Tikta (Bitter)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka –  Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf
Dosage- 5 to 10 ml of juice

Chemical constituents of Plectranthus amboinicus
The aerial parts of the plant yield an essential oil (0.1%) which contains thymol (79.5%); whereas in leaves carvacrol and camphor are major constituents. Leaves also contain a large amount of oxalacetic acid, flavonoid, cirsimaritin and beta- sitosterol.

तीक्ष्णा पर्णयवान्युष्णा कटुतिक्ता रसे लघुः । दीपनी पाचनी रुच्या मलसंग्राहिणी परम् ॥
अग्निमान्द्ये यकृद्रोगे ग्रहण्यामुदरक्रिमौ । विषूचिकायामश्मर्या मूत्रकृच्छ्रे च शस्यते॥      ( द्र.गु.वि)

Uses of Indian borage:

  • The juice from the crushed leaves of Parnayavani is given in a dose of 5 -6 ml with honey to treat cough and rhinitis.
  • The fresh juice of Coleus amboinicus is given in dose of 10 ml with hot water to treat intestinal worms.
  • The juice of the plant is given with juice of ginger to improve appetite and treat indigestion.
  • The paste and juice of the leaf is given internally to treat renal and urinary calculi.
  • The juice of Parnayavani is given with decoction of Kutaja (Holarrhena antidysentrica) to treat diarrhea and irritable bowel syndrome.
  • The paste of the leaf is applied over forehead to treat headache.
  • Expressed juice of leaf  is applied around the orbit to relieve the pain in conjunctivitis
  • Juice is mixed with sugar is given to children in colic, in asthma, chronic cough, strangury, calculus, gonorrhoea, piles and dyspepsia
  • Crushed leaves are used as local application to the head in headache and to relieve the pain and irritation caused by centipedes
  • Expressed juice is applied around the orbit to relieve the pain in conjunctivitis
  • The drug is also useful in cardiac disability,cough,breathlesness,hiccups,dysurea and urinary calculi
  • Expressed juice of leaves are carminative and used in dyspepsia
  • The drug is used in vatavyadhi(akshepaka, apatantraka).It is also considered as useful in hridroga
  • This drug is diuretic herbal agent. Its leaves have a plesant odour and pungent taste
  • The drug is quite useful in disorders of digestive system,particularly gastrointestinal complaints.

Adverse effects of country borage:
No adverse effect is known after the use of parnayavani. Some people suffer from burning sensation of the tongue and esophagus after the intake of juice of the leaf.

Ayurvedic medicines containing Coleus amboinicus
Byekof syrup: Byekof Syrup is a proprietary Ayurvedic medicine useful to treat cough, asthma and other respiratory disorders.

Grahanimihira taila: Grahanimihira Taila is an Ayurvedic oil used in the treatment of diarrhea, fever, cough, etc. This oil is used both for external and internal administration.

Research articles related to Coleus amboinicus:
Anti- microbial study:  Ethanolic extract of Coleus amboinicus leaves were used for study of antimicrobial activity. The antimicrobial activity was evaluated against six bacterial strains with four different concentrations by detecting minimum inhibitory concentration and zone of inhibition. The highest antibacterial activity was observed in Salmonella typhi at a concentration of 1000µg/ml. The lowest antibacterial activity was observed in Staphylococcus aureus at a concentration of 250µg/ml of ethanolic extract of Coleus amboinicus leaf extract.

Anti- bacterial  and Anti- fungal action:  The aim of this study was to evaluate anti-bacterial anti-fungal activity of six Lamiaceae family coleus plants based on their traditional uses (breast-milk stimulants) from two Asian countries. All leaf extracts showed activity at least against one strain of bacteria and the result shows that there were significant differences (p<0.05) between the activities on microorganism. The minimum inhibitory concentration of all leaves extracts ranged from 1.0 to 2.0 mg/ml in inhibiting the growth of S. aureusE. coliP. aeruginosa and B. subtilis. This study shows that the coleus plants leaves can be used as anti-bacterial anti-fungal agent apart from the breast-milk stimulation properties.

Anti- oxidant and cytotoxic action: The aetylacetate and ethanolic extracts of Plectranthus amboinicus, (Lour.) Spreng. Leaves were found to exhibit antioxidant activity with IC50 value 350.74 µg/mL and 281.26 µg/mL by DPPH method. The ethanolic and aetylacetate extracts showed a high antioxidant activity by ß-Carotene-Linoleic Acid Method. N-hexane and aetylacetate extracts showed potent cytotoxic effect on MCF7 with IC50 63.644 µg/mL, 7.647 µg/mL respectively.

Classical categorization:
Priya Nighantu- karpooradi varga

Scientific classification
Kingdom: Plantae
Order: Lamiales
Family: Lamiaceae
Genus: Plectranthus
Species: P. amboinicus

 


Jupha – Hyssopus officinalis : Medicinal uses, Adverse effects,Research & Pharmacology

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Jupha – Hyssopus officinalis : Medicinal uses, Adverse effects,Research & Pharmacology

 

Jupha- Hyssopus officinalis is a plant used for the treatment of swelling, constipation, distention of the abdomen, intestinal worms, hepatomegaly, cough and rhinitis. 

Latin name- Hyssopus officinalis Linn.
Family-Laiatae

Names in different languages:
Hindi name – Jupha

English name – Hyssop
Malayalam name – Isop
Urdu name – Zufah
Chinese – Ngau sat chou
Dutch – Hysop
French – Hysope, Hese saesu
German – Eisop
Greek – Issopos
Hebrew – Esuv
Hindi – Jupha,
Iceland – Isopus
Italian – Issopo
Japanese – Hissopu
Korean – Harob
Norwegian – Hissopo
Russian – Issop
Spanish – Hisopo
Swedish – Isop

Morphology of Hyssopus officinalis:
Jupha is a small plant spreading in the ground level and is found in the Himalayan belt. The stem is woody at the base, from which grow a number of straight branches. Its leaves are lanceolate, dark green in color, and from 2 to 2.5 cm (0.79 to 0.98 in) long. The leaves have small hair like structure and have a pleasant odor and bitter taste. The flowers are pinkish to purplish in color and have pleasant odor.  They bloom from July to September. The fruit is brown in color and slightly triangular in shape.

Properties:
Rasa (Taste) – Katu (Pungent), Tikta (Bitter)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Whole plant
Dosage- 3 to 6 g powder

 

Chemical constituents of Hyssopus officinalis:
Hyssop contains terpenoids, including marrubiin; a volatile oil consisting mainly of camphor, pinocamphone and beta-pinene; flavonoids, glucosides, tannins and resin. Marrubiin is a strong expectorant. The plant also contains ursolic acid, an anti-inflammatory principle. The alcoholic extract of the aerial parts at flower- ing yields an active antioxidant com- pound, rosmanol-ethyl ether. Its activity is much greater than butylated hydroxyl toluene. Pinocamphone and isopino camphone are toxic constituents of the essential oil.

जूफा तीक्ष्णा कटुतिक्ता वीर्योष्णा कफवातनुत् ।
शोथघ्नी लेखनी पित्तसारणी कृमिनाशिनी॥   ( द्र.गु.)

Uses of Jupha:

  • A tea made from the leaves is used in the treatment of flatulence, stomach aches, upper respiratory tract infections, and coughs in children.
  • A poultice made from the herb is used to heal wounds.
  • The paste of the leaf is applied over wound for healing.
  • Cold infusion of the leaf is given in a dose of 40 ml to treat hepatomegaly and fever.
  • The paste of the leaf is applied over the forehead to treat rhinitis and headache.
  • Fresh juice of the leaf and flower is given in a dose of 10 ml to treat constipation and distention of abdomen.
  • The decoction of the leaf is given in a dose of 25 ml to treat intestinal worms.
  • The juice of the leaf is given with honey to treat cough and asthma.
  • The essential oil is used in aromatherapy. This oil should not be used on people who are highly strung as it can cause epileptic symptoms. This oil should not be used internally expect under professional supervision.
  • Externally used as a re-solvent particularly for ecchymosis of eye and eyelids. Oil is used to treat cold cough and lung complains.

 

Adverse effect of Hyssop: The essential oil of the plant in excess quantity can cause increased intestinal movement and diarrhea. Apart from the above features it can also cause epileptic attack in person susceptible to strong odor.

Ayurvedic medicines containing Jupha:
Gojihwadi kashaya: It is an Ayurvedic medicine in water decoction form. It is used in the treatment of fever, cough, bronchitis, asthma etc.

P-KOF syrup: P-KOF Syrup is a proprietary Ayurvedic medicine indicated in Ayurvedic treatment of cold, cough and allergic conditions.

Research articles related to Hyssopus officinalis:
Anti- asthmatic action: It has been proved that Uygur herb Hyssopus offcinalis L. could affect the levels of some cytokines (such as IL-4, IL-6, IL-17, and IFN-γ) in asthmatic mice. By detection of the expressions of MMP-9 and TIMP-1 and the morphological changes, the aim of this research is to reveal the mechanism of Uygur herb Hyssopus offcinalis L. in the process of airway remodeling. It is suggested that Uygur herb Hyssopus offcinalis L. could inhibit airway remodeling by correcting imbalance of MMP-9/TIMP-1 ratio.

Ulcero protective action: Ethanolic extract of Hyssopus officinalis (EEHO) at the dose of 100 and 125 mg/kg was administered to albino rats 1 hour before the administration of ethanol. Animals were there then sacrificed and tissue homogenate was used for various biochemical parameters in order to explore the ulcero- protective and antioxidant potential of the plant. Administration of 1 ml of ethanol to overnight fasted rats resulted in increased ulcer index, total acidity and decreased pH.  The findings of the study indicate that pre-treatment with EEHO has a significant ulcero- protective and antioxidant activity in ethanol-induced ulcers.

Scientific classification
Kingdom: Plantae
Order: Lamiales
Family: Lamiaceae
Subfamily: Nepetoideae
Tribe: Mentheae
Genus: Hyssopus
Species: H. officinalis

Gana – Traditional classification: 
Tulasyadi Varga- Adarsha Nigantu

 

Pudina (Mentha piperata): Medicinal uses, Adverse effects,Research & Pharmacology

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Pudina (Mentha piperata): Medicinal uses, Adverse effects,Research & Pharmacology

 

Pudina – Mentha piperata is a plant which is used for the treatment of indigestion, pain in joints, diarrhea, cough, dysmenorrhea and fever.  

Latin name- Mentha piperata Linn. Mentha spicata
Family- Labiate

Names in different languages:
All the Indian languages like Hindi, Bengali, Kannada, Gujarathi, Malayalam, Tamil, Telugu etc use the name Pudina for the plant. In English the plant is known as Spearmint or Garden mint.

Arabic – Phujanaj
Bengali name – Pudina
Burmese name – Bhudina
Canada – Chetni-maruga
Hindi – Podina
Malayalam – Putina
Marathi name – Pudina

Synonyms:
Rochani- Improves the taste perception

Pahari- Grow in the cool climate of hills
Pudina, Putiha, Pudina, Podinaka, Phudino, Podina

Morphology:
Mentha piperata is a perennial herb growing in the hilly regions or in the cold climatic regions of India. The plant has a strong odor and grows to a height of 1-2 foot. The leaves are slimy, dark and have a strong odor. The flowers are purple in color.Mentha spicata is also used as a synonym for Mentha piperata.

Pudina medicinal properties:
Rasa (Taste) – Katu (Pungent)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf, oil extract
Dosage-
Leaf juice- 5 to 10 ml

Cold infusion- 25 to 30 ml
Oil- 1 to 3 drops

Chemical constituents of Mentha piperata:
The major constituents of the essential oil are: menthol, menthone, pule- gone, menthofuran, 1,8-cineole, menthyl acetate, isomenthone. The leaves contain flavonoid glycosides, eriocitrin, luteolin 7-O-rutinoside, hesperi- din, isorhoifolin, diosmin, eriodictyol 7-O-glucoside and narirutin, besides rosmarinic acid, azulenes, cholene, carotenes.

रोचनी वह्रिजननी वक्त्रजाड्यनिशूदनी |
कफवातहरी बल्या चर्द्यर्ह्रोचकवारिणी॥      ( आ. वि)

Medicinal uses of mint leaves: 

  • Pudina is used in many cuisines all over the world, to enhance the taste of the dish.
  • The leaves of Mentha piperata is used as carmative and helps in digestion of the food.
  • 1-3 drops of oil obtained after the processing from the plant is used with hot water to treat indigestion and relive colic pain.
  • The paste of the leaf of Mentha piperata is applied over the joints to relive pain and localized inflammation.
  • Cold infusion of the plant in a dose of 30-40 ml is used to relieve dysmenorrhea and fever.
  • The fresh juice of the leaf of Pudina, in a dose of 5 to 10 ml is given with honey to relieve cough and sore throat.
  • The paste of the leaf is applied over the skin to relieve itching sensation and wound associated with pus.
  • The distillate of the leaf is extracted and used in a dose of 1 to 3 drops with hot water to treat indigestion and bloating of abdomen.
  • Gargling is done by adding fresh juice of the leaf of Pudina with water to relieve bad odor from the mouth and treat inflammation of the gums.
  • The paste of the leaf of Pudina is given with first morsel of food to treat intestinal worms.

Adverse effect:
Although it is used in many consumer products, mint may cause allergic reactions in some people, inducing symptoms such as abdominal cramps, diarrhea, headaches, heartburn, tingling or numbing around the mouth, anaphylaxis or contact dermatitis.

Formulations containing Putiha:
Antharth oil and liniment: It is a proprietary medicine useful to relive joint pain, reduce morning sickness and localized inflammation after external application.

Appirich syrup: Appirich Syrup is a proprietary Ayurvedic medicine useful as an appetizer in children. It improves taste in food and makes the child to feel hunger and eat well.

Calcurosin syrup: It is a proprietary Ayurvedic medicine useful to treat urinary bladder calculi and kidney stones.

Capsin cream: It is a cream used for external application in treating joint pain, muscle spasm and arthritis.

Kofsil syrup: Kofsil Syrup is a non-sedative herbal cough syrup. It is used in the treatment of bronchial asthma, bronchitis, bronchospasm, allergic asthma and smoker’s cough.

Acidowin tablet: It is a proprietary Ayurvedic medicine useful to treat hyperacidity, flatulence, reflux oesophagitis and motion sickness.

Research articles related to Mentha piperata:
Anti-bacterial action: The antibacterial activity of peppermint oil and different extracts of Mentha piperita against some Gram-positive and Gram-negative bacterial strains was evaluated in the present research work by agar well diffusion method. The oil and extracts also exhibited significant antioxidant activity and the oil showed about half potency when compared to the standard BHT.

Anti- diabetic action: The present study was undertaken with an objective to observe effectiveness of oral administration of Peppermint juice in alloxan induced diabetic wistar rats. The present experimental study provides further evidence that oral administration of Peppermint juice for 21 days produced a significant decrease (p <0.0010) in the blood glucose level of alloxan induced diabetic rats.

Wound healing action: The objective of this study was to evaluate the effects of topical Mentha piperita and Cymbopogan citratus oil on wound healing. Diabetic induced infected wound treatment with topical Mentha piperita ointment treatment and their another essential ointment in Cymbopogan citratus wound contraction studies a circular piece08 mm2 in area 20th days compared wound healing study on the wound contraction studies a circular piece 08mm2 in area 18th days highly effective in Mentha piperita ointment.

Anti- fungal action: Essential oil of Mentha piperita was analyzed by GC and GC-MS and evaluated for in vitro antifungal activity against Dreschlera spiciferaFusarium oxysporum f.sp. ciceris and Macrophomina phaseolin. The oil was found to be effective against these fungal pathogens under laboratory screening. The antifungal activities of the oil increased with an increase in the concentration.

Anti-emetic action in chemotherapy: This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha × piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV). The treatment and placebo groups applied essential oils of M. spicata, M. × piperita, or a placebo, while the control group continued with their previous antiemetic regimen. There was a significant reduction in the intensity and number of emetic events in the first 24 h with M. spicata and M. × piperitain both treatment groups (p < 0.05) when compared with the control and no adverse effects were reported. The cost of treatment was also reduced when essential oils were used.

Classical categorization:
Bhavaprakash Nighantu – Anekaryanam varga
Nighantu Adarsha – Putikaranjadi varga
Dhanavantari Nighantu – Suvarnadi varga

Scientific classification
Kingdom      –     Plantae

Phylum        –     Angiospermae
Class            –     Dicotyledons
Subclass       –     Asteridae
Family         –      Labiatae
Genus          –      Mentha
Species        –      Spicata

 

Priyangu- Callicarpa macrophylla: Medicinal uses, Adverse effects,Research & Pharmacology

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Priyangu- Callicarpa macrophylla: Medicinal uses, Adverse effects,Research & Pharmacology

 

Priyangu – Callicarpa macrophylla is an Ayurvedic coolant herb used for the treatment of headache, diarrhea mixed with blood (Ulcerative colitis), general debility, fever, pain in the joints, skin diseases etc. 

Latin name- Callicarpa Macrophylla Vahl.
Family- Verbenaceae

Names in different languages:
Hindi  name                          : Phalini, Daya

English name                        : Beutyberry
Bengali name                        : Matara, Mathara
Gujarati name                       : Priyangu
Kannada name                     : Priyangu
Malayalam name                 : Gawhla, Nalal, Jativruksha
Marathi name                       : Garhala
Punjabi name                        : Priyang, Sumali
Tamil name                           : Ittauduga, Vettilai pattai, Seembakulthu
Telugu name                         : Kodauduga

 

 

Sanskrit synonyms:
Gandhaphali- The fruit has a strong odor

Phalini- The plant bears many fruits
Asthibandhana- Binds the bones together
Gochandana, Shyama, Pitatandula, Karamba, Priya, Durjara, Kanta, Priyahva, Vanita, Lata, Shyama, Godantini,
Kanguni, Kangu,
Priyavalli, Vrutta, Govandani, Karambha, Varnabhedani, Mahilahvaya, Vishvak Senangana Priya, Bhangura, Mangalya, Shreyasi

Morphology of Callicarpa macrophylla:
Priyangu is a perineal shrub growing up to 2m height found in North eastern parts of India and at 3000 ft in Himalayan region. Branches have hairy like cotton structure. The leaves are 18 to 30cm long ovate as lanceolate, smooth from upper surface and hairy from ventral surface. The flowers are small, pink appears in florescence, some are purple or pinkish purple in color. The fruits are fleshy white divided into 4 compartments, each having single seed, ripe fruits look spongy.

Callicarpa macrophylla medicinal properties:
Rasa (Taste) – Tikta (Bitter), Kashaya (Astringent), Madhura (Sweet)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature)
Vipaka –  Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Sheeta (Cold)
Karma (Actions) – Tridosha shamaka (Balances down all the three doshas)

Part used- Flower, Bark, Root
Dosage-
Powder- 3 to 5 g

Decoction- 30 to 40 ml

Callicarpa macrophylla Chemical constituents:
Oil from root is aromatic and stomachic. Calliterpenone (3-0X0-13β – Karane- 16α   , A –diol)   and its acetate are seen in seeds, leaves and aerial parts. Crategolic acid, 2α – hydroxyursolic acid, ursolic acid, β-Sitosterol, β-D-glucoside, apigenin, luteolin, their 7-0-glucuronides 3, 3’-7 trime thoxy-4’, 5- dihydroxy-flarone (CNF-1) L(t)- α- amino- β-(P-methoxyphenyl), Propronic acid, C22 –C24 fatty acids, ethyl ester of C23 fatty acid are obtained from leaves. A new diterpenoid- Isopropylidenocalliterpenone is isolated from essential oil of leaves along with calliterpenone and its monoacetate and characterized as 16α, 17-Iso propylideno-3-oxo-phyllocladane.

Medicinal Uses of Priyangu:      

  • The berries are highly astringent but are made into wine and jelly.
  • The paste of the bark is applied over forehead to treat headache.
  • The powder of the bark of Priyangu is used for rubbing the gums to treat gingivitis and used in face pack to improve the complexion of the face.
  • The powder of the bark is used as dusting powder to control the bleeding from wounds.
  • The decoction of the bark of Callicarpa macrophylla is given in a dose of 30-40 ml to stop internal bleeding in cases of peptic ulcer, internal piles.
  • The cold infusion of the bark or root of Callicarpa macrophylla is given in a dose of 50 ml to treat fever and burning sensation of the body.
  • The dried powder of Priyangu 92 to 3 g) is given with milk to improve the strength of the body.
  • The paste of the bark is applied externally to treat skin diseases.
  • The cold infusion of the bark or root is given in a dose of 40 ml which acts as blood purifier.
  • Oil processed with leaf or bark of Priyangu is applied over the joints having swelling and pain.

THERAPEUTIC USES:
Shitada Priyangu + Musta+ Triphala are made into paste applied over gums. – Cha. Chi-4/70
Parinama shula
: Vomitting is induced with leaf decoction of Priyangu. –  Cha. Su-26
Jvara:
 Priyangu is best for Jvara, which contains Madhur rasa, Shita virya Dha. Ni/Cha. Su-26

If bleeding does not stop, methods to stop it should be adopted, orifice of wound should be smeared with powder of Priyangu, Yasti, Masha etc. –A. H. Su 27/48.
Decreases Pitta. It comes under group Which mitigates pitta. A. H. Su 15/6

It cures chronic diahorrea, heal fractures, good for pitta, healing ulcers –A. H. Su- 15/37
It helps in unification of broken parts, fractures of bones, makes body stout, and hard to digest. –A. h. Su- 6/12
Priyangu
 is Shitala, tikta cures delusion, burning sensation, fever, vomiting and dyserasia.- Cha.chi.90
It is also used in rheumatic pain, colic tumors, dysentery, loss of appetite, blood disorders, bleeding disorders, Pittaprameha, skin disorder, general debility and poison.

 

Uses as per Ayurveda:
Bhagnasandhana Krut – useful in healing fractures
Brumhani – nourishing, nutritious

Indicated in –
Daurgandhya – bad odor
Sweda – excess sweating
Daha –  burning sensation, as in gastritis, neuropathy, burning sensation in eyes etc
Jwara – fever
Gulma – Tumors of the abdomen
Trushna – excessive thirst
Visha – Toxic conditions, poisoning
Moha – delusion
Vanti – vomiting
Bhranti – dizziness

Fruit:
Madhura – sweet

Rooksha – dry
Kashaya – astringent
Sheetala – coolant
Guru – heavy to digest
Vibandhakrut – causes constipation
Adhmanakrut – causes bloating
Balakrut – improves strength
Sangrahi – absorbent, useful in diarrhea, IBS
Kaphapitta jit – Balances Kapha and Pitta Dosha.

Adverse effects: No known adverse effect is reported or known after the use of Priyangiu

Ayurvedic medicines containing Priyangu:
Devadarvarishta: Devadarvarishta is an Ayurvedic medicine, traditionally used to treat skin diseases especially occurring due to complication of diabetes, difficulty in passing urine and digestive diseases.

Ushirasava: Ushirasava is a liquid Ayurveda medicine used in treating bleeding disorders, skin diseases, intestinal worms, inflammatory conditions and piles.

Pippalyasava: It is a liquid ayurvedic medicine used in treating cough, asthma, anemia, piles and irritable bowel syndrome.

Amroid ointment: This is a proprietary ayurvedic medicine useful to treat piles, bleeding per rectum and local inflammation around the anal opening.

Research articles on Callicarpa  macrophylla:
Anti- bacterial activity: In this study, researchers investigated the ex vivo antibacterial activity of C. macrophylla stem ethanolic (SEE) and aqueous extracts (SAE) against various gram positive and gram negative strains. SEE have fairly growth inhibitory activity against all the bacterial strains, but exceptionally SAE was inactive against all except Salmonella typhimurium.

Wound healing action: In this present study ethanolic polyherbal extract including that of C.macrophylla is screened for its phytochemical evaluated in wound healing activity in Wister rats by excision wound model using povidone iodine as a reference standard. From the results it was found that Polyherbal  ethanolic extract possess significant wound healing action when compared to control and equipotent wound healing activity when compared to standard povidine iodine.

Classical categorization:
Charaka –

Mutravirajaniya – group of herbs that colour and cleanse urine
Purisha samgrahaniya – group of herbs that increase bulk of stools

Sushruta – Priyangvadi gana, Anjanadi gana
Astanga sangraha – Anjanadi gana
Bhavaprakash Nighantu – Karpooradi varga
Dhanwantari Nighantu –Chandanadi varga
Kaiyyadeva Nighantu- Dhanya varga, Oushadhi varga
Raja Nighantu- Chandanadi varga

Scientific classification
Kingdom – Plantae

Sub kingdom – Phanero gamia
Division – Angio spermae
Class – Dicotyledons
Subclass – Gamopetalae
Family – Verbanaceae
Genus – Callicarpa
Species – Macrophylla

Literary review:
The drug Priyangu is first mentioned in Charaka samhita, useful in Raktapitta.

In Astanga sangraha, mentioned as Priyangvadi gana, Anjanadi gana.
In Sushruta samhita, mentioned under the same. It is Shitada, Kaphapittahara. It is useful in Jvara, Daha, Trishna, Gulma, etc.

By Nighantus:

  1. Dhanwantari Nighantu, it pacifies kaphaand pittadosha. Useful in burning sensation, headache, excessive perspiration, ulcers, rheumatoid arthritis.
  2. Bhavaprakasha Nighantu: Includes Raktatisara, Jvara, Daha, Gulma, it is Kapapittajit and 
  3. Madanpal Nighantu, also describes as Raktasangrahaniya gana, Pittanashini, for Vrishya 
  4. Raja Nighantu, also includes gana’sas Mutra-virajaniyaPurish sangrahaniya.
  5. In Nighantu Ratnakar, described the varieties as named Gandhpriyangu, it is Shitain nature, useful in KeshyaDahapitta, Raktaruja, Vatagulma, visha, meha, meda, malastambhakar also 

Also considered as Srotogamitva and also Adhmanakara, it is Guru in nature, Shita, Ruksha.

Varieties:
According to classical reference of Bheda:

Two types:
1. Dhanyapriyangu – Setaria italica is source of food grain. Dhanya means grain. Hence, this is considered as Dhanya Priyangu (also called Aushadha priyangu).
2. Gandhapriyangu – Prunus mahaleb, Algaia roxburghiana mig, Callicarpa tomentose (L.) murray

Habitat:
It is found in North -eastern parts of India and at 3000 ft in Himalayan region. Found in village shrubberies and gardens through out north -east India, west Bengal – abundant plant.

 

Bhandira - Clerodendrum infortunatum: Medicinal uses, Adverse effects,Research & Pharmacology

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Bhandira - Clerodendrum infortunatum: Medicinal uses, Adverse effects,Research & Pharmacology

 

Bhandira- Clerodendrum infortunatum is an Ayurvedic herb used for the treatment of wounds, skin diseases, liver disorders, intestinal worms, fever and joint pain. 

Latin name- Clerodendrum infortunatum Linn.
Family- Verbenaceae

Names in different languages:
Hindi name  – Bhant, Ghato

English name – Hill glory bower
Bengali name – Bhant, Ghentu
Gujarathi name – Bhanua
Kannada name – Basavana Pada, Ibbane
Marathi name – Bhandira, Kari, Bhat
Malayalam name – Peruku, Peravellam
Punjabi name – Kalibasuti
Tamil name – Perugilai, Karukanni
Telugu name – Basavanapadu, Gurrapu
Burmese name – Bujiphyu, Kaaungguly
Nepalese name – Chitu
Uttaranch name – Bhanua

Sanskrit Synonyms:
Bhandir, Bhandi, Bhantaka

Clerodendrum infortunatum morphology:
It is a flowering shrub or small tree, and is so named because of its rather ugly leaf. The stem is erect, 0.5–4 m high, with no branches and produce circular leaves with 6 inch diameter. The flowers are white with purplish pink or dull-purple throat, pubescent. Fruit berry, globose, turned bluish-black or black when ripe, enclosed in the red accrescent fruiting-calyx. The stem is hollow and the leaves are 6-8 inch (15–20 cm) long, borne in whorls of four on very short petioles. The inflorescence is huge, consisting of many tubular snow white flowers in a terminal cluster up to 2 ft (0.6 m) long. The tubes of the flowers are about 4 inch (10 cm) long and droop downward, and the expanded corollas are about 2 inch (5 cm) across. The fruits are attractive dark metallic blue drupes, about a half inch in diameter. Fruit usually with 4 dry nutlets and the seeds may be with or without endosperm. It flowers from April to August.

Bhandeera medicinal properties:
Rasa (Taste) – Tikta (Bitter)

Guna (Qualities) – Laghu (Light), Ruksha (Dry), Teekshna (Strong)
Vipaka – – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf is the main used part.
Root and flowers are also used rarely.
Dosage-
Decoction- 10 to 20 ml

Chemical constituents of Clerodendrum infortunatum:
The major compounds are sterols, sugars, flavonoids and saponins. Novel crystalline compounds such as clerodolone, clerodone, clerodol and a sterol designated clerosterol have been isolated from the root. Seven sugars namely raffinose, lactose, maltose, sucrose, galactose, glucose and fructose were identified. Fumaric acid, caffeic acid esters, β-sitosterol and β-sitosterol glucoside were isolated from the flowers. Apigenin, acacetin and a new flavone glycoside, characterised as the methyl ester of acacetin-7-0-glucuronide are isolated from the flowers. Saponin is one of the major compounds of the leaf. 24 beta-ethylsterols, clerosterol and 22-dehydroclerosterol, 24-methyl-sterols (24-methylcholestanol, 24-methylcholesterol, 24-methyl-22-dehydrocholesterol, and 24-methyllathostero) and 24 beta-ethyl-22-dehydrocholestanol are found in the seeds. Scutellarin and hispidulin-7-O-glucuronide are present in the leaf. Poriferasterol and stigmasterol are the components of the aerial parts.

Distribution:
It is found throughout India, commonly in forest and in road side, as weed.

It grows about 0.9 – 2.4 metre height.
It is also found in Ceylon, Malayan region, found in temperate region of India.

Medicinal Uses of Bhandira:

  • The fresh juice of the leaves of Bhandira is applied over the wounds for quick healing.
  • The paste of the leaves of Clerodendrum infortunatum is applied over the area having localized swelling to reduce it.
  • The fresh juice of the leaf of the plant is given in a dose of 10 ml to treat liver disorders and remove intestinal worms.
  • Cold infusion of the leaf is given in a dose of 30 ml to purify the blood in skin diseases.
  • Fresh juice of the leaf is given in a dose of 10 to 115 ml to treat fever.
  • The cold infusion of the leaf of Clerodendrum infortunatum is given in a dose of 30 ml to treat indigestion and improve the digestive capacity.
  • The leaves of this plant are used as vermifuge and root rubbed down with butter milk is administered in colic pain.
  • The fresh juice of the leaf acts as a laxative and is used to treat constipation.

Uses as per Ayurveda:
Rechana – induces purgation

Krumighna – Relieves worm infestation, useful in infected wounds
Sara – induces mobility, causes diarrhea, purgation, relieves constipation
Vishaghna – anti toxic
Ruchya – improves taste, relieves anorexia.

Indication:
Jwara – fever

Kushta – skin diseases
Amavata – rheumatoid arthritis
Madhumeha – diabetes
Raktapitta –Bleeding disorders such as nasal bleeding, heavy periods, etc  

Adverse effects:  No adverse effect of Bhandira is known or reported.

Formulations containing Bhandira:
Rasnadi ghrita: Rasnadi ghritam is a herbal medicated ghee formulation used for the treatment of rheumatoid arthrits and Vata related disorders associated with pain.

Agastya rasayana: It is a ayurvedic medicine in lehya form used for the treatment of respiratory diseases like cough, asthma, bronchitis and to strengthen the lungs.

Bala oil: It is a medicated oil used for the treatment of vata predominat diseases like joint pain, paralysis, facial palsy, sciatica etc

Vathapy capsule: It is a proprietary ayurvedic medicine in capsule form for the treatment of hemiplegia and paraplegia.

Bronkasav liquid: It is a proprietary ayurvedic medicine useful to treat asthma, cough and other respiratory diseases.

Infectex granules: It is a proprietary ayurvedic medicine in granule form and is used for the treatment of Leucorrhoea, Gonorrhea, Dysmenorrhea and other Genito-urinary infections.

Research articles related to Clerodendrum infortunatum:
Anti- microbial potency: The present study was conducted to determine the antimicrobial activity of C.infortunatum (Verbenaceae) with two different solvents viz; ethanol and ethyl acetate against medically important pathogens such as six gram positive bacterial strains, nine gram negative bacterial strains and seven fungal strains. Most of the extracts of root, leaf and stem of C. infortunatum are effective against both organisms; bacteria and fungi, especially leaf extract > root extract > stem extract.

Wound healing action: Validation of the ethno therapeutic claim of Clerodendrum infortunatum L. was investigated to evaluate its wound-healing potency in experimental rats. The chloroform and ethanol extract showed significant (P< 0.01) results compared with the control. The presence of bioactive constituents, including flavonoids, is thought to promote the wound-healing process due to their antioxidant and antimicrobial activities.

Hepato protective potential: Hepatoprotective potential of methanolic extract of Clerodendrum infortunatum Linn. (MECI), which is widely used in Indian indigenous system of medicine, was studied against carbon tetrachloride induced hepatotoxicity in rats. The study was evaluated by assaying the serum biochemical parameters glutamate pyruvate transaminase (ALT), glutamate oxaloacetate transaminase (AST), alkaline phosphatase (ALP), bilirubin and total protein. The results of this study revealed that methanol extract of C. infortunatum has moderate hepato- protective activity. This effect may be due to the ability of the extract to inhibit lipid peroxidation and increase in the anti-oxidant enzymatic activity.

Systemic classification:
Kingdom         :           Plantae

Phylum            :           Plantae
Class                :           Discotyledons
Subclass          :           Gamopetale
Order               :           Ver benaceae
Family             :           Ver benaceae
Genus              :           Cleroden drum
Species            :           Viscosum
Sub Kingdom  :           Phanerogamia

Controversies: 

  • In Samhitas, the herb Bhandir” has not been mentioned; instead, he mentioned Tanduliyaka which belongs to different family (Amaranthaceae), according to some authors.
  • Tanduliyaka has also been given synonyms Bhandi, Bhandira by “Bhavamisra”.
  • Bhandir the drug does not match with the Bhandi described by Charaka Sutra sthana.
  • Bhandi of Susrutha cikitsa is identified as manjista.
  • Dalhana identified Bhandi as Lady’s fingure.
  • Bapal vaidya considers clerodendron infortunatum Linn as one of the sources of Granthi parna.

 

Pudina (Mentha piperita): Medicinal uses, Adverse effects,Research & Pharmacology

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Pudina (Mentha piperita): Medicinal uses, Adverse effects,Research & Pharmacology

Pudina -Mentha-piperita-4.jpg

 

Pudina – Mentha piperata is a plant which is used for the treatment of indigestion, pain in joints, diarrhea, cough, dysmenorrhea and fever.  

Latin name- Mentha piperata Linn. Mentha spicata
Family- Labiate

Names in different languages:
All the Indian languages like Hindi, Bengali, Kannada, Gujarathi, Malayalam, Tamil, Telugu etc use the name Pudina for the plant. In English the plant is known as Spearmint or Garden mint.

Arabic – Phujanaj
Bengali name – Pudina
Burmese name – Bhudina
Canada – Chetni-maruga
Hindi – Podina
Malayalam – Putina
Marathi name – Pudina

Synonyms:
Rochani- Improves the taste perception

Pahari- Grow in the cool climate of hills
Pudina, Putiha, Pudina, Podinaka, Phudino, Podina

Classical categorization:
Bhavaprakash Nighantu – Anekaryanam varga
Nighantu Adarsha – Putikaranjadi varga
Dhanavantari Nighantu – Suvarnadi varga

Scientific classification
Kingdom      –     Plantae

Phylum        –     Angiospermae
Class            –     Dicotyledons
Subclass       –     Asteridae
Family         –      Labiatae
Genus          –      Mentha
Species        –      Spicata

Pudina -Mentha-piperita-1.jpg

Morphology:
Mentha piperata is a perennial herb growing in the hilly regions or in the cold climatic regions of India. The plant has a strong odor and grows to a height of 1-2 foot. The leaves are slimy, dark and have a strong odor. The flowers are purple in color.Mentha spicata is also used as a synonym for Mentha piperata.

Pudina medicinal properties:
Rasa (Taste) – Katu (Pungent)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf, oil extract
Dosage-
Leaf juice- 5 to 10 ml

Cold infusion- 25 to 30 ml
Oil- 1 to 3 drops

Chemical constituents of Mentha piperata:
The major constituents of the essential oil are: menthol, menthone, pule- gone, menthofuran, 1,8-cineole, menthyl acetate, isomenthone. The leaves contain flavonoid glycosides, eriocitrin, luteolin 7-O-rutinoside, hesperi- din, isorhoifolin, diosmin, eriodictyol 7-O-glucoside and narirutin, besides rosmarinic acid, azulenes, cholene, carotenes.

रोचनी वह्रिजननी वक्त्रजाड्यनिशूदनी |
कफवातहरी बल्या चर्द्यर्ह्रोचकवारिणी॥      ( आ. वि)

Medicinal uses of mint leaves: 

  • Pudina is used in many cuisines all over the world, to enhance the taste of the dish.
  • The leaves of Mentha piperata is used as carmative and helps in digestion of the food.
  • 1-3 drops of oil obtained after the processing from the plant is used with hot water to treat indigestion and relive colic pain.
  • The paste of the leaf of Mentha piperata is applied over the joints to relive pain and localized inflammation.
  • Cold infusion of the plant in a dose of 30-40 ml is used to relieve dysmenorrhea and fever.
  • The fresh juice of the leaf of Pudina, in a dose of 5 to 10 ml is given with honey to relieve cough and sore throat.
  • The paste of the leaf is applied over the skin to relieve itching sensation and wound associated with pus.
  • The distillate of the leaf is extracted and used in a dose of 1 to 3 drops with hot water to treat indigestion and bloating of abdomen.
  • Gargling is done by adding fresh juice of the leaf of Pudina with water to relieve bad odor from the mouth and treat inflammation of the gums.
  • The paste of the leaf of Pudina is given with first morsel of food to treat intestinal worms.

Pudina -Mentha-piperita-2.JPG

Adverse effect:
Although it is used in many consumer products, mint may cause allergic reactions in some people, inducing symptoms such as abdominal cramps, diarrhea, headaches, heartburn, tingling or numbing around the mouth, anaphylaxis or contact dermatitis.

Formulations containing Putiha:
Antharth oil and liniment: It is a proprietary medicine useful to relive joint pain, reduce morning sickness and localized inflammation after external application.

Appirich syrup: Appirich Syrup is a proprietary Ayurvedic medicine useful as an appetizer in children. It improves taste in food and makes the child to feel hunger and eat well.

Calcurosin syrup: It is a proprietary Ayurvedic medicine useful to treat urinary bladder calculi and kidney stones.

Capsin cream: It is a cream used for external application in treating joint pain, muscle spasm and arthritis.

Kofsil syrup: Kofsil Syrup is a non-sedative herbal cough syrup. It is used in the treatment of bronchial asthma, bronchitis, bronchospasm, allergic asthma and smoker’s cough.

Acidowin tablet: It is a proprietary Ayurvedic medicine useful to treat hyperacidity, flatulence, reflux oesophagitis and motion sickness.

Cultivars variety

Mentha × piperita 'Candymint'. Stems reddish.
Mentha × piperita 'Chocolate Mint'. Flowers open from bottom up; reminiscent of flavour in Andes Chocolate Mints, a popular confection.
Mentha × piperita 'Citrata'. Includes a number of varieties including Eau De Cologne Mint, Grapefruit Mint, Lemon Mint, and Orange Mint. Leaves aromatic, hairless.
Mentha × piperita 'Crispa'. Leaves wrinkled.
Mentha × piperita 'Lavender Mint'.
Mentha × piperita 'Lime Mint'. Foliage lime-scented.
Mentha × piperita 'Variegata'. Leaves mottled green and pale yellow.
"Mentha suaveolens" 'Apple Mint'. Foliage is light green and hairy. Used as a ground cover and for cooking

 

Pudina -Mentha-piperita-3.jpg

Research articles related to Mentha piperata:
Anti-bacterial action: The antibacterial activity of peppermint oil and different extracts of Mentha piperita against some Gram-positive and Gram-negative bacterial strains was evaluated in the present research work by agar well diffusion method. The oil and extracts also exhibited significant antioxidant activity and the oil showed about half potency when compared to the standard BHT.

Anti- diabetic action: The present study was undertaken with an objective to observe effectiveness of oral administration of Peppermint juice in alloxan induced diabetic wistar rats. The present experimental study provides further evidence that oral administration of Peppermint juice for 21 days produced a significant decrease (p <0.0010) in the blood glucose level of alloxan induced diabetic rats.

Wound healing action: The objective of this study was to evaluate the effects of topical Mentha piperita and Cymbopogan citratus oil on wound healing. Diabetic induced infected wound treatment with topical Mentha piperita ointment treatment and their another essential ointment in Cymbopogan citratus wound contraction studies a circular piece08 mm2 in area 20th days compared wound healing study on the wound contraction studies a circular piece 08mm2 in area 18th days highly effective in Mentha piperita ointment.

Anti- fungal action: Essential oil of Mentha piperita was analyzed by GC and GC-MS and evaluated for in vitro antifungal activity against Dreschlera spiciferaFusarium oxysporum f.sp. ciceris and Macrophomina phaseolin. The oil was found to be effective against these fungal pathogens under laboratory screening. The antifungal activities of the oil increased with an increase in the concentration.

Anti-emetic action in chemotherapy: This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha × piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV). The treatment and placebo groups applied essential oils of M. spicata, M. × piperita, or a placebo, while the control group continued with their previous antiemetic regimen. There was a significant reduction in the intensity and number of emetic events in the first 24 h with M. spicata and M. × piperitain both treatment groups (p < 0.05) when compared with the control and no adverse effects were reported. The cost of treatment was also reduced when essential oils were used.

 

 

Double Coconut, sea coconut or Coco de mer Medicinal uses

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Double Coconut, sea coconut or Coco de mer

Botanical Name: Lodoicea maldivica

 

Kingdom:

Plantae

(unranked):

Angiosperms

(unranked):

Monocots

(unranked):

Commelinids

Order:

Arecales

Family:

Arecaceae

Subfamily:

Coryphoideae

Tribe:

Borasseae

Genus:

Lodoicea
Comm. ex DC.

Species:

L. maldivica

 

 Double Coconut, sea coconut or Coco de mer-Lodoicea maldivica

 

English: Double Coconut Palm, double coconut, the sea coconut, love nut,  coco fesse, or Seychelles nut.

Malayalam: Aklarithenga (അക്ളാരിത്തേങ്ങാ, അക്ലാരിത്തേങ്ങാ

)

French: Coco de mer. The name coco de mer is French, and means "coconut of the sea".

 

Lodoicea, commonly known as the sea coconut, coco de mer, or double coconut, is a monotypic genus in the palm family. The sole species, Lodoicea maldivica, is endemic to the islands of Praslin and Curieuse in the Seychelles. It formerly also was found on the small islets of St Pierre, Chauve-Souris and Ile Ronde (Round Island), all located near Praslin, but had become extinct there for a time until recently reintroduced. The name of the genus, Lodoicea, is derived from Lodoicus, the Latinised form of Louis, in honour of King Louis XV of France.

Maldive coconut, Lodoicea maldivica, this very large nut looks like two coconuts joined together, side by side. Maldive coconut has been classified very close to coconut, but is not related to the coconut. It belongs to the Borassoid group of palms. Maldive coconut is the world’s largest and heaviest seed, a single seed may be 12 inches long, nearly three feet in circumference and weigh 20kg. The Maldive coconut palms grow only on a small island named Praslin in the Seychelles. Plants of these nuts are tender and very slow-growing, the nut takes a year to germinate and another year to form its first leaf.

The tree generally grows to 25–34 m tall. The tallest on record, measured on the ground after felling, was 186 feet (56.7 meters) in total height. The leaves are fan-shaped, 7–10 m long and 4.5 m wide with a 4 m petiole in mature plants. However juveniles produce much longer petioles; up to 29' 6" (9 meters) or even 33 feet (10 meters). It is dioecious, with separate male and female plants. The male flowers are arranged in a catkin-like inflorescence up to 1 m long which continues to produce pollen over a ten-year period; one of the longest living inflorescences known. The mature fruit is 40–50 cm in diameter and weighs 15–30 kg, and contains the largest seed in the plant kingdom. The fruit, which requires 6–7 years to mature and a further two years to germinate, is sometimes also referred to as the sea coconut, love nut, double coconut, coco fesse, or Seychelles nut

 

Double Coconut, sea coconut or Coco de mer-Lodoicea maldivica

Morphology

Leaves

The crown is a rather dense head of foliage with leaves that are stiff, palmate up to 10 m in diameter and petioles of two to four meters in length. The leaf is plicate at the base, cut one third or more into segments 4–10 cm broad with bifid end which are often drooping. A triangular cleft develops at the petiole base. The palm leaves form a huge funnel that intercepts particulate material, especially pollen, which is flushed to the base of the trunk when it rains. In this way, Lodoicea improves its nutrient supply and that of its dispersal-limited offspring.

 

Flowers

This species of palm is diecious (where male and female flowers are borne on different plants).

 

Inflorescence

 

Inflorescences are interfoliar, lacking a covering spathe and shorter than the leaves. The staminate inflorescence is catkin-like, one to two metres long and generally terminal and solitary, sometimes two or three catkins may be present. The pistillate inflorescences are also one to two metres long unbranched and the flowers are borne on a zig-zagging rachilla.

The clusters of staminate flowers are arranged spirally and are flanked by very tough leathery bracts. Each has a small bracteole, three sepals forming a cylindrical tube, and a three-lobed corolla. There are 17 to 22 stamens. The pistillate flowers are solitary and borne at the angles of the rachis and are partially sunken in it in the form of a cup. They are ovoid with three petals as well as three sepals. It has been suggested that they may be pollinated by animals such as the endemic lizards which inhabit the forest where they occur. Pollination by wind and rain are also thought to be important. Only when Lodoicea begins to produce flowers, which can vary from 11 years to 45 or more, is it possible to determine the sex of the plant. The nectar and pollen are also food for several endemic animals e.g. bright green geckos (Phelsuma sp.), white slugs (Vaginula seychellensis) and insects.

 

Double Coconut, sea coconut or Coco de mer-Lodoicea maldivica

Fruit

The fruit is bilobed, flattened, 40 to 50 cm long ovoid and pointed, and contains usually one but occasionally two to four seeds. The epicarp is smooth and the mesocarp is fibrous. The endosperm is thick, relatively hard, hollow and homogenous. The embryo sits in the sinus between the two lobes. During germination a tubular cotyledonary petiole develops that connects the young plant to the seed. The length of the tube is reported to reach about four metres. In the Vallee de Mai the tube may be up to 10 m long.

 

Lodoicea was once believed to be a sea-bean or drift seed, a seed evolved to be dispersed by the sea. However, it is now known that the viable nut is too dense to float, and only rotted out nuts can be found on the sea surface,thus explaining why the trees are limited in range to just two islands.

Ripe interior (endosperm) of coco-de-mer is normally like jelly, not firm and white like cocos nucifera (coconut). Maldive coconut is also said to be a powerful aphrodisiac still used in Asian herbal medicine.

 

Double Coconut, sea coconut or Coco de mer-Lodoicea maldivica

 

seeds

The seeds usually have two lobes and can weigh up to an enormous 30 kg.

The fruit contains usually one but occasionally two to four seeds. The mature fruit is 40-50 cm in diameter and weighs 15-30 kg, and contains the largest seed in the plant kingdom. The fruit, which requires 6-7 years to mature and a further two years to germinate.

Lodoicea was once believed to be a sea-bean or drift seed, a seed evolved to be dispersed by the sea. However, it is now known that the viable nut is too dense to float, and only rotted out nuts can be found on the sea surface, thus explaining why the trees are limited in range to just two islands.

The seeds germinate in about one year and must have available a thickness of the soil of at least 1,5 metres, as the hypocotyl which develops from the seed, and on which extremity stands the germ which will originate the first leaf, goes down up to this depth.

 Double Coconut, sea coconut or Coco de mer-Lodoicea maldivica

Pollination

The Double Coconut or Coco de Mer is unique among palm tree species in that there are distinct male and female palms. The female palms grow the fruits. The male palms are taller, more slender and have catkins growing on them. The small flowers on the catkins of the male palm have a strong scent, produce large amounts of nectar and are very small.

The flowers on the female tree produce a similar scent to the male flowers, but the scent is less strong. Only one flower is active on a female tree at any one time and then for only for a few hours each day. There has been some debate about how Coco de Mer palms are pollinated. It is now believed that their primary pollinator is a long legged fly, the Ethiosciapus bilobatus.

 

The Uses of Double Coconut or Coco de mer

 

Food Uses

The Double coconut or Coco de Mer fruit is edible, but is not commercially available due to the restricted distribution and difficulty in cultivating the plant.

The real purpose of the fruit, the edible part is the endosperm of the fruit that is succulent and a delight to the taste buds. In case of the immature seeds they tend to contain a jelly like substance that melts in the mouth with a sweet taste. This is treated as a delicacy and is enjoyed by the locals. In food, it is typically found as flavor enhancers for soups in southern Chinese cuisine, namely cuisine around the Canton country.

Medical Uses

Back in old times this plant was used for its medicinal properties that helped in wading off many life threatening diseases. The fruit is used in Ayurvedic medicine  like kashaya mridha sanjivini gulika, sidha medicines for diabetes, vomiting and libido and also in traditional Chinese medicine. The jelly-like flesh of Coco de Mer was considered to have medicinal properties.

 

Coco de mer. The name coco de mer is French, and means "coconut of the sea".

 

History and mythology

Formerly Lodoicea was known as Maldive coconut. Its scientific name, Lodoicea maldivica, originated before the 18th century when the Seychelles were uninhabited. In centuries past the coconuts that fell from the trees and ended up in the sea would be carried away eastwards by the prevailing sea currents. The nuts can only float after the germination process, when they are hollow. In this way many drifted to the Maldives where they were gathered from the beaches and valued as an important trade and medicinal item. This association is reflected in one of the plant's archaic botanical names, Lodoicea callipyge Comm. ex J. St.-Hil., in which callipyge is from Greek words meaning 'beautiful buttocks'. Other botanical names used in the past include Lodoicea sechellarum Labill. and Lodoicea sonneratii (Giseke) Baill.

 

Until the true source of the nut was discovered in 1768 by Dufresne, it was believed by many to grow on a mythical tree at the bottom of the sea. European nobles in the sixteenth century would often have the shells of these nuts polished and decorated with valuable jewels as collectibles for their private galleries. The coco de mer tree is now a rare and protected species.

 

The natives of the Maldive islands have heard of the local name of Maldive coconut, as Thaavah Kaashi, but mysteriously many at present are not even aware of the shape of it. The local name Thaavah Kaashi has been in the Dhivehi vocabulary for centuries and hard shell of the Maldive coconut is still used in local medicine for sexual enhancement purposes

 

Lodoicea, commonly known as the sea coconut, coco de mer, or double coconut, is a monotypic genus in the palm family

Plants Details In India

Scientists at the Indian Botanical Garden in West Bengal’s Howrah district have carried out artificial pollination of the only double coconut tree in India, which bears the largest seed known to science.

 

One of the rare and globally threatened species of palm, the double coconut ( Lodoicea maldivica) tree was planted at the botanical garden in 1894 and the artificial pollination is a result of decades of work by scientists of the Botanical Survey of India (BSI).

 

“The tree took almost a hundred years to mature and when it started flowering, we started looking for this particular palm species in this part of world. We collected some pollen from palms from Sri Lanka but could not successfully pollinate it. Finally, with the help of pollen from another tree in Thailand, the pollination process was successful,” BSI Director Paramjit Singh told The Hindu.

 

 

Research Paper

  1. Chemical Characterization of Lodoicea maldivica Fruit by Sebastiani B1, Giorgini M2, Falcinelli S3. : Chem Biodivers. 2017 Aug;14(8). doi: 10.1002/cbdv.201700109. Epub 2017 Jul 6

Abstract

In the present study, we report the attempt to characterize the chemical composition of fruit kernel of Lodoicea maldivica coco nucifera palm (commonly named as 'Coco de mer') by gas chromatographic method. The analysis was performed by HS-SPME and GC/MS techniques to determine volatile aroma, sterol, and fatty acid composition profiles in the internal and external pulp of two distinct coconuts. Although no qualitative differences in flavour composition were observed between the two analysed coconuts and the relative two pulp parts, variations in the abundance levels of the prominent compounds have been recorded. The averaged quantity of total phytosterols, resulting from the two analysed 'Coco de mer' samples, was almost constant in both kernels coconut, being 24.5 μg/g (of dry net matter) for the external, and 26.9 μg/g (of dry net matter) for the internal portion. In both coconuts, the fatty acid pattern composition was characterized by seven saturated acids ranged from C14:0 (myristic) to C20:0 (arachidic) and two monounsaturated acids, the palmitoleic (C16:1, ω7) and the oleic (C18:1, ω9). Palmitic acid (C16:0) was the predominant one with an average contribution of about 49.0%, followed by pentadecanoic 16.5%, stearic (C18:0) 11.6%, and myristic (C14:0) 9.9% acids in all two examined kernel portions.

 

  1. Molecular identification of Lodoicea maldivica (coco de mer) seeds by Chun-yin Makcorresponding author1 and Chuen-shing Mok : Published online 2011 Sep 30. doi: 1186/1749-8546-6-34

Abstract

The edible endosperm of Lodoicea maldivica with the common name of coco de mer is used in Chinese medicine for treating cough. Native to Seychelles, Lodoicea maldivica seeds have commanded high prices for centuries due to its scarcity. This study aims to develop a molecular identification method for the authentication of Lodoicea maldivica seeds. The PRK gene of Lodoicea maldivica was successfully amplified and sequenced for identification.A new molecular method for the identification of Lodoicea maldivica seeds in fresh, frozen or dried forms was developed.

 

complete plant

Maldive coconut, Lodoicea maldivica, this very large nut looks like two coconuts joined together

 

 youtube video  Link

https://www.youtube.com/watch?v=wLFLHgFl3TQ

 

Moringa oleifera (Drumstick tree) -Medicinal uses, Adverse effects,Research & Pharmacology

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Moringa oleifera (Drumstick tree) - Medicinal uses, Adverse effects,Research & Pharmacology

 

Scientific classification

Kingdom:

Plantae

Clade:

Angiosperms

Clade:

Eudicots

Clade:

Rosids

Order:

Brassicales

Family:

Moringaceae

Genus:

Moringa

Species:

M. oleifera

 

Moringa-oleifera-tree

 

 

Moringa oleifera, also known as horseradish tree, ben tree, or drumstick tree, is a small tree from India, Pakistan, and Nepal that has been used for generations in Eastern countries to treat and prevent diseases such as diabetes, heart disease, anemia, arthritis, liver disease, and respiratory, skin, and digestive disorders.

Moringa oleifera is the most widely cultivated species of the genus Moringa, which is the only genus in the family Moringaceae. English common names include: moringa,  drumstick tree  horseradish tree (from the taste of the roots, which resembles horseradish), ben oil tree, or benzoil tree . It is a fast-growing, drought-resistant tree, native to the southern foothills of the Himalayas in northwestern India, and widely cultivated in tropical and subtropical areas where its young seed pods and leaves are used as vegetables. It can also be used for water purification and hand washing, and is sometimes used in herbal medicine.

 

 

Botanical name: Moringa oleifera

Family: Moringaceae

Kannada name: Nugge mara, Nugge kayi

 

 

English

Horse radish tree, Drum stick tree, The Horse-Radish Tree, Ben Oil Tree

 

Assamese

Sajna, Sajina

Marathi

Shevga शेवगा

Malayalam

Muringai

Konkani

Mashinga मशींग

Hindi

Murungakka/ Munuga/ Murung/ Murung-a-kai/ Shewga, Senjana सेंजन

Tamil

Moringa, Sohajna, Murungamaram,முறுங்கை Murungai

French

Bèn ailé, Benzolive, Moringa, Ben oléifère, Arbre radis du cheval

 

German

Behenbaum, Behenussbaum, Flügelsaniger Bennussbaum, Pferderettichbaum

Italian

Sàndalo ceruleo

Portuguese

Acácia branca, Cedra (Brazil), Marungo, Moringuiero, Muringa

 

Spanish

Árbol del ben, Ben, Morango, Moringa

 

Moringa-oleifera

 

Sanskrit Synonyms:

Shobhanjana – Very auspicious tree

Shigru – has strong, piercing qualities

Teekshnagandha – Strong and pungent odor

Aksheeva – relieves intoxication

Mochaka – helps to cure diseases

 

Morphology

  1. oleifera is a fast-growing, deciduous tree that can reach a height of 10–12 m (32–40 ft) and trunk diameter of 45 cm (1.5 ft). The bark has a whitish-grey colour and is surrounded by thick cork. Young shoots have purplish or greenish-white, hairy bark.

 

Flower

In axillary, divaricate panicles; white. Flowering throughout the year.

Fruit

An elongate, torulose capsule, angled, longitudinally 3-valved; seeds many, 3 angled, 3 winged. Fruiting throughout the year.

Field tips

Bark corky grey, exuding yellowish-white gum.

Leaf Arrangement

Alternate-spiral

Leaf Type

Tri-pinnate

Leaf Shape

Ovate or elliptic

Leaf Apex

Rounded

Leaf Base

Rounded

Leaf Margin

Entire

 

 

Classical categorization:

Charaka Samhita  , Krimighna , Svedopaga , Shirovirechanopaga , Katuka Skandha

Charaka has also mentioned it as a plant source for oil – Sthavara Sneha Yoni 

 

Sushruta and Vagbhata – Varunadi gana

 

Medicinal Qualities of drumstick tree:

Rasa  – Katu ,Tikta

Guna– Laghu , Rooksha , Teekshna

Vipaka – katu

Veerya – Ushna

Effect on Tridosha – Balances Kapha and Vata.

 

Parts used: Drumstick’s root bark, stem bark, leaves, fruits and seeds

 

 

Health benefits of Moringa:

There are three varieties of Moringa explained in Ayurvedic text books.

  1. Shyama – black variety
  2. Shveta – white variety and
  3. Rakta – red variety. It is also called as Madhu shigru.

 

benefits Black variety drumstick uses

Katu,Teekshna ,Ushna ,Madhura , Laghu ,Deepana ,Rochana ,Rooksha ,Kshara ,Tikta ,Vidaahakrit ,Sangrahi ,Shukrala ,Hridya , Pittarakta prakopana,Chakshushya, Kaphavataghna,Vidradhi ,Shvayathu  , Krimi ,Meda, Apachi, Visha , Pleeha , Gulma ,Ganda Vrana

 

White variety drumstick uses:

 

It is quite similar to the black variety.

Dahakrut – causes burning sensation

pleehaanaaM vidradhim hanti – useful in splenic abscess

VraNaghna – helps in quick wound healing

pittaraktakrut – Increases Pitta and vitiates blood.

 

The red variety ( Madhushigru)

 

Deepana – Increases digestion power.

Sara – promotes proper bowel movements.

 

Drumstick leaves and bark

The juice extract of drumstick leaves and bark are very useful in relieving pain. They act as natural analgesic. They are used both for oral intake and also for external application as paste.

In Indian household, the leaves are used to prepare Chutney or sambar.

The paste of moringa leaves are applied as paste externally to relieve pain and inflammation.

It is applied over pile mass to relieve pain and itching.

Moringa leaves are used internally to improve eye sight, also for the treatment of Ulcerative colitis.

 

Drumstick seeds uses

Chakshushya – good for eyes

Vishanashana – anti toxic

Avrushya – do not have aphrodisiac qualities

Nasyena Shiro Artinut – When used for Nasya (in the form of powder or oil), it helps to relieve headache.

Moringa seeds are called as Shweta Maricha.

 

Moringa for headache:

As explained above, moringa leaves paste applied externally, or used as vegetable helps to relieve headache.

Its seed powder, in the form of nasya treatment cures headache.

 

Moringa for diabetes Many studies have been conducted to prove the anti diabetic and anti oxidant effect of Moringa.

 

Moringa flowers are useful in intestinal worms. It balances Pitta and kapha.

 

Oil prepared with Moringa is useful to relieve headache, pungent, useful in skin diseases and diabetes.

 

Moringa leaves for balanitis: Leaves are ground to make a paste. It is applied over the inflamed area.

 

Moringa-oleifera-seed

 

 

Moringa in Ayurvedic medicines:

Because of its analgesic effects, Moringa is used as an ingredient in many Ayurvedic pain relief oils such as Murivenna, Kottamchukkadi Thailam,

Because of its anti inflammatory effects, it is an ingredient of Shothaghna Lepa – a paste application used to relieve swelling, pain and redness.

Because of its wound healing benefits, and usefulness in abscess etc, it is an ingredient in Aragwadhadi kashayam

 

Moringa Side Effects:

As explained above, it causes increase in burning sensation and is pungent. Hence,people with gastritis or sensitive stomach should use this vegetable carefully.

It is not ideal to be taken during periods, since it increases Pitta and vitiates blood.

It is also not ideal to be taken during bleeding disorders.

 

Drumstick during pregnancy and lactation:

Drumstick fruit is rich in protein, vitamins, minerals and anti oxidants. Hence it can be used during pregnancy. But Drumstick leaves, root bark and flowers are not indicated during pregnancy.

 

It is not ideal to take this soon after delivery. However, a couple of weeks after delivery, this can be used.

 

Drumstick to increase sperm count:

The drumstick fruit is known to improve sperm count and quality.

Drumstick (Moringa) leaf powder was evaluated m. on male reproductive system of Swiss albino mice Mus musculus. The sperm count, its mobility and mortality, histology of testis and epididymis of normal and hyperglycaemic male Swiss albino mice have been investigated and attempt has been taken to evaluate the efficacy of Moringa leaf powder in repair mechanism in case of hyperglycaemia. In treated mice (Group III), the sperm count significantly increased, sperm mobility also increased but sperm mortality decreased significantly. There was a slight decrease in weight of testis (0.478±0.008gm to 0.33±0.006 gram) respectively when compared to control mice group. (research)

 

Moringa seeds for colitis:

An experimental study conducted on rats concluded that MSHE (Moringa oleifera seeds hydro-alcoholic extract) and MCF (chloroform fraction ) were both effective to treat experimental colitis and this might be attributed to their similar major components, biophenols and flavonoids. Since the efficacy was evident even in low doses of MSHE, presence of active constituents with high potency in seeds is persuasive. (Source).

 

 

Moringa_flower

 

Cultivation and Production

Moringa oleifera development is achieved in two main ways: sowing and cutting.

 

Traditionally in Sudan the seeds are preferred while vegetative propagation is common in India, Indonesia and in some areas of West Africa

 

Sowing requires selection of the seeds, when they are easily available and human labor is limited, while the possibility to transplant seedlings allows flexibility in field planting even if it requires extra labor and costs.

 

Seeds germinate within two weeks, at a maximum 2 cm depth. When sowing is planned in nursery, the seedlings can be transplanted when they reach about 30 cm (3–6 weeks after germination).

 

The number of seeds per kilogram ranges from 3000 to 9000, depending on the variety, with a germination rate of 80%–90% for ideal storage conditions (3 °C, 5%–8% moisture). However, the viability decreases if seeds remain at ambient temperature and high relative humidity, their germination rate dropping to 7.5% after three months.

 

Cutting is preferred when seeds availability is scarce and/or when labor is not a limiting factor. Ramachandran et al. reports that plants raised from seeds produce fruits of poorer quality, while Animashaun et al. suggest that trees grown from seeds develop longer roots (an advantage for stabilization and access to water) compare to that grown from cuttings that have much shorter roots.

 

When hard woodcuttings (1–2 m long 4–16 cm diameter [8,15]) from adult trees are planted during the rainy season burying one third in the soil, they readily develop roots that in few months reach a considerable size [16]. Moringa oleifera is an exceptionally fast growing tree, in three months it can be 3 m high and in few years reaches 12 m if it is left to growth naturally. Since the tree vigorously re-sprouts after cutting, pruning or pollarding are usually practiced to enhance lateral branching and give the tree a bush shape in order to facilitate the harvest. Nevertheless, since literature reports about the good practice management of Moringa oleifera are scant, practical trials are needed. Leaves and seeds are the parts of the plant of interest. Accordingly, the spatial distribution in planting Moringa oleifera trees is designed to facilitate the relevant harvest and the management practices.

 

 

For production of leaves, Moringa oleifera plantation can be designed as follows:

 

(i) intensive production with spacing ranging from 10 cm × 10 cm to 20 cm × 20 cm, harvest interval between 35 to 45 days, irrigation and fertilization are needed;

(ii) semintensive production with spacing about 50 cm × 100 cm, harvest interval between 50 to 60 days, irrigation and fertilization suggested;

(iii) integrate in an agroforestry system with spacing distance of 2–4 m between rows, harvest interval around 60 days, fertilization and irrigation not strictly necessary.

Production decreases from intensive production to less dense spacing (agroforestry system), although a tremendous variability can be observed for a given spatial distribution and the same cultivation management. For example, the yield of an intensive plantation can range from 580 to 40 m/ha/year , being season dependent with the largest yield in wet or cold season. There is a need for further studies to assess optimum spacing and harvest intervals that comply with the different climates and production systems . Harvest can be mechanical or manual. Shoots are cut at a 0.5–1 m height above the ground; but leaves can be picked directly off the tree; this practice, however, albeit quicker, leads to a less vigorous re-growth.

 

For the production of seed a low density plantation has a positive effect on yields: typically 2.5 × 2.5 m or 3 × 3 m triangular pattern . Fruits (trilobite capsule), referred as pods (brown color and dry and split longitudinally), ripen about three months after flowering and must be harvested as soon as possible. Each pod usually contains about 26 1-cm diameter seeds lined by three whitish papery leaflets on the edge. Like for leaves, also the production of seed shows a tremendous variability. A single tree can produce from 15.000 to 25.000 seeds with an average weight of 0.3 gr per seed [21]; moreover early flowering varieties produce pods in six month, while other varieties require more than one year. After pruning, branches develop new pods within 6 months

Moringa oleifera leaf, raw

Nutritional value per 100 g (3.5 oz)

Energy

64 kcal (270 kJ)

Carbohydrates

8.28 g

Dietary fiber

2.0 g

Fat

1.40 g

Protein

9.40 g

Vitamins

(%DV)

Qty

Vitamin A equiv.

(47%)

378 μg

Thiamine (B1)

(22%)

0.257 mg

Riboflavin (B2)

(55%)

0.660 mg

Niacin (B3)

(15%)

2.220 mg

Pantothenic acid (B5)

(3%)

0.125 mg

Vitamin B6

(92%)

1.200 mg

Folate (B9)

(10%)

40 μg

Vitamin C

(62%)

51.7 mg

Minerals

 

Calcium

(19%)

185 mg

Iron

(31%)

4.00 mg

Magnesium

(41%)

147 mg

Manganese

(17%)

0.36 mg

Phosphorus

(16%)

112 mg

Potassium

(7%)

337 mg

Sodium

(1%)

9 mg

Zinc

(6%)

0.6 mg

Water

78.66 g

 

 

 

Moringa_oleifera-pod

 

Chemical content in the Moringa

1. Vitamins

Fresh leaves of Moringa oleifera are reported to contain 11,300–23,000 IU of vitamin A . Vitamin A plays key roles in many physiological processes such as vision, reproduction, embryonic growth and development, immune competence, cell differentiation, cell proliferation and apoptosis, maintenance of epithelial tissue, and brain function. Its deficiency is still prevalent in many developing countries, and considered responsible for child and maternal mortality

Fresh leaves of Moringa oleifara are also a good source of carotenoids with pro-vitamin A action. They contain 6.6–6.8 mg/100 g

β-carotene is more concentrated in the dried leaves, with amounts ranging from 17.6 to 39.6 mg/100 g of dry weight (DW) [

Moringa oleifera is an interesting source of vitamin C. Fresh leaves contain approximately 200 mg/100 g

Moringa oleifera fresh leaves are a good source of vitamin E (in particular α-tocopherol) and contain approximately 9.0 mg/100 g

Among vitamins of group B, only thiamine, riboflavin and niacin seem present in Moringa oleifera leaves. These vitamins mainly act as cofactors of many enzymes involved in the metabolism of nutrients and energy production, and their concentration in fresh leaves ranges between 0.06 and 0.6 mg/100 g, 0.05 and 0.17 mg/100 g and 0.8 and 0.82 mg/100 g for thiamine, riboflavin and niacin, respectively

We did not find studies about other vitamin of group B or vitamin D and K in Moringa oleifera leave; therefore further studies on this topic are needed.

2. Polyphenols

Moringa oleifera dried leaves are a great source of polyphenols.

3. Flavonoids

Flavonoids are a sub-group of polyphenolic compounds having a benzo-γ-pyrone structure and are ubiquitous in plants, as they are synthesized in response to microbial infections Epidemiological studies have consistently shown that high intake of flavonoids has protective effects against many infectious (bacterial and viral diseases) and degenerative diseases such as cardiovascular diseases, cancers, and other age-related diseases

4. Phenolic Acids

Phenolic acids are a sub-group of phenolic compounds derived from hydroxybenzoic acid and hydroxycinnamic acid, naturally present in plants. Thanks to their documented effects on human health, the contribution of food-supplied phenolic acids is a subject of increasing interest. In particular, these compounds are mainly studied for their documented antioxidant, anti-inflammatory, antimutagenic and anticancer properties . Particularly abundant in fruit and vegetables, phenolic acids were found in great amounts in Moringa oleifera leaves too. In dried leaves, gallic acid seems to be the most abundant, with a concentration of approximately 1.034 mg/g of DW

5. Alkaloids

Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This nitrogen may occur in the form of a primary amine (RNH2), a secondary amine (R2NH) or a tertiary amine (R3N). In addition to carbon, hydrogen and nitrogen, most alkaloids contain oxygen . Alkaloids are of particular interest thanks to their pharmacological properties. The presence of these compounds has been confirmed in Moringa oleifera leaves [

6. Glucosinolates and Isothiocyanates

Glucosinolates are a group of secondary metabolites in plants. Structurally they are β-S-glucosides of thio-oxime-O-sulfates and synthesized from amino acids. Appreciable amounts of these compounds were found in Moringa oleifera leaves. In particular, around 116 and 63 mg/g of DW in young and older leaves, respectively, are reported and isothiocyanates play an important role in health promoting and prevention of disease

7. Tannins

Tannins are water-soluble phenolic compounds that bind to and precipitate alkaloids, gelatin and other proteins. They exhibit various biological properties: anti-cancer, antiatherosclerotic, anti-inflammatory, anti-hepatoxic, antibacterial and anti-HIV replication activity

8. Saponins

Saponins are a group of natural compounds that consist of an isoprenoidal-derived aglycone, designated genin or sapogenin, covalently linked to one or more sugar moieties

9. Oxalates and Phytates

Oxalates and phytates are anti-nutritional compounds as they bind minerals inhibiting the intestinal absorption. Moringa oleifera leaves present high contents of these compounds

 

 Moringa-oleifera-Drumstick-Flower

 

Pharmacology

 

 

1. Antioxidant Properties

Moringa oleifera leaves are a rich source of antioxidant compounds

Many in vitro studies on antioxidant activity of Moringa oleifera leaves are available in literature Siddhuraju and Becker  examined the radical scavenging capacities and antioxidant activities of the aqueous, aqueous methanol, and aqueous ethanol extracts of freeze-dried leaves of Moringa oleifera from different agro-climatic regions. The authors found that different leaves extracts inhibited 89.7%–92.0% peroxidation of linoleic acid and had a scavenging activity on superoxide radicals in a dose-dependent manner (EC50 within the range of 0.08–0.2 mg/mL, with the exception of water extract from Indian leaves which has an EC50 > 0.3 mg/mL). All of the solvent extracts of leaf samples had a very high radical scavenging activity, however better results were obtained in methanol and ethanol extracts. Both methanol and ethanol extracts of Indian origins showed the highest antioxidant activities

In conclusion, many in vitro and in vivo studies have shown antioxidant properties of Moringa oleiferaleaves. These findings may be explained by the abundant amounts of antioxidant compounds in the leaves. However further studies in human are needed to confirm the results obtained in animals.

7.2. Anti-Inflammatory and Immunomodulatory Properties

Inflammation is a protective immunovascular response that involves immune cells, blood vessels, and molecular mediators. The purpose of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and to initiate tissue repair.

The anti-inflammatory properties of Moringa oleifera seeds have been so far reported in a number of studies, while only few studies on anti-inflammatory effect of leaves are available in the literature.

7.3. Hypoglycemic Properties

Hypoglycemic effects of Moringa oleifera leaves are reported in literature.

In the study of Ndong et al.  male spontaneously diabetic Goto-Kakizaki (GK) rats and non-diabetic male Wistar rats received a single dose of glucose solution and a dose Moringa oleifera leaves (2 g/kg BW and 200 mg/kg BW, respectively), whereas control groups of both animals only received a single dose of glucose solution. Blood glucose concentration was measured at 0, 10, 20, 30, 45, 60, 90 and 120 min. Results from OGTT shown that Moringa oleifera significantly decreased blood glucose at 20, 30, 45, and 60 min in GK rats compared to the control and at 10, 30 and 45 min Wistar rats compared to the control after glucose administration. Moreover, in GK rats, the treatment with Moringa oleifera leaves reduced AUC values by 23%, whereas it did not significantly affect these values in control rats. These results suggest that Moringa oleifera has a glucose intolerance ameliorating effect in both GK and Wistar rats, with a greater action in diabetic than in normoglycemic rats. Kar et al. tested hypoglycaemic activity of ethanol extract (95%) of some Indian medicinal plants, including Moringa oleifera, in alloxan-induced diabetic rats. The authors found that a single dose of 250 mg/kg BW of leaves extract determined a halving of serum glucose in a week. In the study of Jaiswal et al. [135], the effect of the aqueous extract of Moringa oleifera leaves on glucose homeostasis was tested in healthy and streptozotocin-induced sub, mild and severely diabetic Wistar rats (STZ, a cytotoxic drug that selectively destroys islet β cells). The dose of 200 mg/kg BW of leaves extract determined a maximum fall of 26.7% in fasting blood glucose concentration and a maximum fall of 29.9% in OGGT at 3 h after glucose administration. The same dose determined a maximum fall of 31.1% and 32.8% in OGGT in sub and mild diabetic rats, respectively. Severely diabetic rat were, instead, long treated (21 days) with aqueous extract of Moringa oleifera leaves. The experiment revealed a fall of 25.9%, 53.5%, 69.2% in fasting blood glucose at 7, 14 and 21 days treatment with leaf extract. Interestingly, results obtained in sub, mild and severely diabetic rats were similar to those obtained in Glipizide treated rats (2.5 mg/kg BW, reference drug). Similar results were obtained by Edoga et al. . In this study, the aqueous extract produced a dose-dependent reduction in blood glucose levels of normoglycemic and hyperglycemic rats. In normoglycemic rats, the aqueous extract of Moringa oleifera (100, 200 and 300 mg/kg) exhibited a reduction of 23.14%, 27.05% and 33.18% respectively of the blood glucose levels within 6 hours of administration, while in alloxan-induced diabetic rats the reduction were of 33.29%, 40.69% and 44.06% respectively. Interestingly, also in this study, similar results were obtained using 200 mg/kg of tolbutamide (reference drug). Divi et al.  tested the antidiabetic properties of aqueous extract of Moringa oleifera leaves in fructose-induced insulin-resistant (IR) and STZ-induced diabetic rats. After administration of 200 mg/kg BW of aqueous extract of Moringa oleifera leaves for 60 days the authors observed a decrease in blood glucose concentration in both groups and a decrease of insulin in IR group compared to respectively control. The hypoglycemic effect of aqueous extract of Moringa oleifera leaves in STZ-induced diabetic rats was also confirmed by Yassa et al. Moreover, in this study histopathological damage of islet cells was also markedly reversed. Moringa oleifera treatment significantly increased the areas of positive purple modified Gomori stained β-cells (from 60% to 91%) and decreased the area percentage of collagen fibers (from 199% to 120%) compared to control values. All these findings were confirmed by other studies using similar approach

William et al. examined the effects of Moringa oleifera leaves added to a standardized meal on serum post-prandial glucose concentration at 1 and 2 h from the consumption, compared to the standard meal alone or a 75 g oral glucose load in type 2 diabetes mellitus patients. Compared to the glucose load, standard meals with or without vegetable supplements induced a significantly lower post-prandial glucose response as derived from AUCs. However, leaf-supplemented meals caused a lower response (−21%) compared to standard meals alone. Moreover, plasma insulin AUCs did not differ significantly between the two meals, suggesting that the hypoglycemic effect of Moringa oleifera leaves supplementation was not due to increased insulin secretion. Kumari examined the hypoglycemic effect of 40-days administration of Moringa oleifera leaves in non-insulin dependent type 2 diabetes mellitus subjects aged 30–60 years old. Recruited subjects were divided in experimental and control group: the first received 8 g of dried Moringa oleifera leaves for 40 days, whereas the control group didn’t receive any treatment. Daily meals were comparable between the two groups in terms of relative food type consumption, nutrients and calories as well. Fasting and post-prandial blood glucose concentrations were taken at baseline and at the end of the experiment. Fasting and post-prandial blood glucose did not differ much from baseline in the control group, while they were significantly reduced in the experimental group (−28% and −26%, respectively). Finally, Ghiridhari et al.  recruited a group of 60 normal weight type 2 diabetes mellitus patients, aged 40–58 years old, on sulfonylurea medication and a standardized calorie-restricted diet (1500 to 1800 Kcal). The patients were equally divided into an experimental and a control groups. Patients in the experimental group were prescribed an unspecified amount of Moringa oleifera leaf for 90 days. The results showed that post prandial blood glucose of experimental group initially was 210 mg/dL and it reduced to 191, 174 and 150 mg/dL respectively after the first, second and third month of supplementation (with a significant decrease of 9%, 17% and 29%, respectively). In control group post prandial blood glucose level of 179 mg/dL was substantially maintained during the whole experiment. Similar trends were observed for glycated hemoglobin (HbA 1c). In the experimental group initial value of 7.81% significantly decreased to 7.4% after the supplementation period, whereas it did not change in the control group. The results indicated that Moringa oleifera leaves are a suitable to reduce the diabetic complications in diabetic patients. However, it should be noted that treatment allocation to patients appear to have not been randomized as baseline values for the two parameters were higher in the experimental group than in the control group, 7.8% ± 0.5% vs. 7.4% ± 0.6% for HbA1c and 210 ± 49 vs. 179 ± 36 mg/dL for post-prandial glucose response Finally, it has been suggested that isothicyanates isolated from Moringa oleiferaleaves reduced glucose production in liver cells, showing activity at very low concentrations and being close to two orders of magnitude more active than metformin. These compounds were able to decrease phosphoenolpyruvate carboxykinase and glucose-6-phosphatase gene expression suggesting that they act via blocking these rate-limiting steps in liver gluconeogenesis

In conclusion, scientific evidences suggest a potential use of Moringa oleifera leaves in the treatment of diabetes. Many compounds isolated in Moringa oleifera leaves may be involved in the glucose homeostasis. Among theme, isothiocyanates seem to reduce insulin resistance and hepatic gluconeogenesis. However, also polyphenol compounds abundant in Moringa oleifera leaves, such as phenolic acids and flavonoids, may contribute to its effects on glucose homeostasis. These compounds exert, indeed, anti-diabetic effects targeting various cellular signaling pathways in pancreas, liver, skeletal muscle and white adipose tissue. In particular, they influence β-cell mass and function, as well as energy metabolism and insulin sensitivity in peripheral tissues. Their effects may be due to antioxidant, enzyme inhibition, receptor agonist or antagonist activity or through novel mechanisms yet to be elucidated . Phenolic compounds, flavonoids and tannins may be also involved in the ability of Moringa oleifera leaves extract to inhibit the intestinal sucrase and, slightly, the pancreatic α-amylase actions  Finally, even though studies on human being highlight the hypoglycemic effects of Moringa oleifera leaves, further larger randomized studies controlled for potential confounders, such as sex, age, race, nutritional status and dietary habits in human are required before using the leaves as herbal drug for the treatment of diabetes.

4. Hypolipidemic Properties

Hypolipidemic effects of Moringa oleifera leaves are reported in literature

Chumark et al. [114] examined the hypolidipemic effects of Moringa oleifera leaves in rabbits fed with high-cholesterol diet (5%) for 12 weeks. A group was concomitantly treated with Moringa oleifera leaves extract (0.1 g/kg BW/day). At the end of the experiment, rabbits treated with Moringa oleifera leaves presented a total cholesterol, LDL, HDL and triglycerides significantly reduced of 52%, 42.7%, 44.2% and 75.4% respectively, compared to rabbits only fed with high-cholesterol diet, with consequent reduction of 86.52% of internal carotid atherosclerotic plaque formation. Similar trends were observed in the group treated with 5 mg/kg BW of simvastatin (reference drug). The anti-dyslipidemic effects of Moringa oleifera leaves were also examined in rats fed with a high-fat diet [151]. In this study, Wistar rats were fed for 30 days with a high-fat diet containing 20% (w/w) fat. Animals were divided in two groups, one of which received a daily dose of 1 g/kg BW of aqueous extract of Moringa oleifera leaves. The authors observed a significant lower increasing of serum cholesterol in treated compared to untreated rats, but not in liver and kidney. The percentage decrease in serum, liver and kidney was 14.35%, 6.40% and 11.09%, respectively. Similarly, Jain et al. [152], fed albino rats, for 30 days, with a high-fat diet containing 26% fat. In this case, three groups received different doses of methanolic extracts of Moringa oleifera leaves (150, 300, or 600 mg/kg bw/die), one group was treated with 4 mg/kg of simvastatin, whereas another group didn’t receive any supplementation. Treatment with methanolic extract, at three different doses significantly decreased the levels of total cholesterol and LDL as compare to the controls. The same was true for VLDL treating rats with the medium and the highest doses of methanolic extracts. Interestingly, the medium and the highest doses of methanolic extracts determined a significant increment of HDL. Similar results were obtained treating rats with simvastatin. In addition, Bais et al. [153] has recently shown that a supplementation of 200 and 400 mg/kg bw/die of Moringa oleifera leaves extract exhibited anti-obesity effects in high-fat fed mice. Lower food intake was observed in the groups treated with Moringa oleiferaleaves extract when compared to the group feed with only high-fat diet. Subsequently, the body weight gain in these groups was significantly lower than the rats feed with only high-fat diet. All these findings were confirmed by other studies using similar approaches [130,153,154].

 

Other studies evaluated the hypolipidemic effects of Moringa oleifera leaves supplementation in diabetes-induced rats. Diabetes is indeed a risk condition to develop dyslipidemia. Oyedepo et al. [140] evaluated the effect of aqueous extract of Moringa oleifera leaves on plasma total cholesterol, triglycerides, HDL and LDL in alloxan-induced diabetic male rats. Diabetic rats were feed with 400 mg/kg BW of aqueous extract of Moringa oleifera leaves for 28 day. At the end of the experiment diabetic rats presented lower plasma total cholesterol, triglycerides and LDL, but not higher HDL, than diabetic rats untreated. Divi et al. [137] observed a decrease of triglycerides (60.1% and 56.4%), total cholesterol (28.8% and 18.0%), LDL (31.2% and 13.9%) and VLDL (60.4% and 56.5%) in both fructose-induced insulin resistant and stz-induced diabetic rats treated with Moringa oleifera leaves extract compared to respectively untreated control. Interestingly, an increment of HDL was observed only in diabetic rats (40.4%), but in IR rats in which a decrement (10.3%) was observed. Similar results were obtained by other studies [141].

Nambiar et al. [155] firstly examined the potential anti-dyslipidemic effect of Moringa oleifera leaves in 35 hyperlipidemic subjects. Subjects were divided control (18 subjects) and experimental (17 subjects) groups. Groups were similar for anthropometric values (age, height, weight, body mass index, waist/hip ratio) and their daily nutrient intake. The experimental group was treated with 4.4 g of dehydrated Moringa oleifera leaves, as four 550 mg tablets twice daily, for 50 days. Plasma lipid profiles were determined at the beginning and at the end of the experiment. The authors observed a significant decrease of 1.6% in plasma total cholesterol and an increment of 6.3% of HDL in experimental group compared to control group. Not significant trends were observed for LDL, VLDL, and triglycerides. However, the TC/HDL ratio significantly decreased by 6.6%, indicating that the treatment induced a lesser atherogenic lipid profile. Kumari [143] observed a significant decrease of total cholesterol (14%), LDL (29%), VLDL (15%) and triglycerides (14%) in diabetic subjects treated with 8 g of Moringa oleifera leaves for 40 days compared to untreated subjects. However, not significant increase of HDL was observed.

In conclusion, scientific evidences suggest a positive effect of Moringa oleifera leaves on lipid homeostasis. Many bioactive compounds may contribute to these effects. It has been suggested that phenolic compounds, in particular flavonoids, play important roles on lipid regulation [156]. Moreover, phenolic compounds of Moringa oleifera leaves extract seem to be involved in the inhibition of pancreatic cholesterol esterase activity reducing and delaying the cholesterol absorption, and binding bile acids by forming insoluble complexes and increasing their fecal excretion with theoretical decreasing of plasma cholesterol level . However, studies on this topic are needed to confirm these hypotheses. Moreover, human are still few, and generally conducted on a restricted number of subjects. Therefore, further larger randomized studies controlled for potential confounders, such as sex, age, race, nutritional status and dietary habits in human are required before using the leaves as hypolipidemic and hypocholesterolemic herbal drug.

5. Hepato and Kidney Protective Properties

Controversial results about the effects of Moringa oleifera leaves on liver and kidney health are reported. Oyagbemi et al.  and Asiedu-Gyekye et al.  observed an increment in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrose (BUN) and creatinine following an administration of the extract of Moringa oleifera leaves in mice. Being biomarkers of liver and kidney injury, the authors speculated that leaves might predispose to hepatic and kidney damage. However, histopathological examinations did not reveal any histological lesions in the sinusoids or central vein  On the other hand, other studies reported hepatic and kidney protective properties against several drugs, such as isoniazid, rifampicin, pyrazinamide, acetaminophen and gentamicin, attributable to Moringa oleifera leaves. The authors observed a reduction of serum ALT, AST, ALP and BUN and creatinine  in animals treated with the extract of Moringa oleifera leaves. These findings were confirmed by histological examinations, which revealed an amelioration of the hepatic and kidney damages induced by drugs, in animals treated with Moringa oleifera leaves. Similar results were obtained by Adeyemi and Elebiyo in rats co-treated with Moringa oleifera leaves and NiSO4 in order to induce nephrotoxicity. Finally, Das et alobserved a reduction of ALT, AST and ALP and a lower liver damage in rats fed with high fat diet and co-treated with Moringa oleifera leaves, suggesting a potential role of the leaves in the prevention of nonalcoholic fatty liver disease (NAFLD).

In conclusion, scientific evidences suggest a potential role of Moringa oleifera leaves in the amelioration of the hepatic and kidney damages induced by drugs in animals. However, further studies on human beings are required before using Moringa as herbal medication.

6. Anticancer Properties

Experimental evidences showed the capacity of Moringa oleifera leaves to protect organism and cell from oxidative DNA damage associated with cancer and degenerative diseases .

Many in Vitro studies evaluated the anticancer properties of both water and alcoholic extracts of Moringa oleifera leaves on different types of tumor cells lines. Sreelatha et al.  found that the aqueous extract of Moringa oleifera leaves exhibited a dose-dependent inhibition of cell proliferation of KB human tumor (KB) cells line. This antiproliferative effect was also associated with an induction of apoptosis, morphological changes and DNA fragmentation. Tiloke et al.  observed a significant increment in reactive oxygen species (ROS) with a concomitant decrease in intracellular GSH levels caused by a reduction in Nrf2 protein (1.89-fold) and mRNA expression (1.44-fold) in human lung cancer cells treated with Moringa oleifera leaves extract compared to untreated cells. These oxidants can react with DNA in the cell determining a DNA fragmentation with consequent death of cell itself. The pro-apoptotic properties of Moringa oleifera leaves extract were also confirmed by the significant increase in p53 protein (1.02-fold) and mRNA expression (1.59-fold), in caspase-9 (1.28-fold) and caspase-3/7 (1.52-fold) activities and an enhanced expression of Smac/DIABLO in cells treated with the extract. Moringa oleiferaleaves extract also caused the cleavage and activation of PARP-1 into 89 and 24 KDa fragments

7. Anti-convulsant

Experiments to discern the effects of M. concanensis leaf ethanol extract on the maximal electroshock seizure test and the pentylene tetrazole-induced convulsion test were conducted on Swiss albino mice (Joy et al., 2013). For both of the tests, M. concanensis inhibited mortality compared to control group in which deaths resulted. The study reported that the extract might block either calcium channels, sodium channels, or NMDA receptors, or has GABA agonist activity.

8. Antimicrobial

Various research has been conducted on Moringa species for their antimicrobial activity. Table summarizes the antimicrobial activity of each species. Moringa species have been widely used as water purifiers and antiseptics for water treatment because of their high antimicrobial activity. Hexane and methanol seed extracts of both M. oleifera and M. stenopetala showed inhibition against waterborne pathogens, particularly against Salmonella typhii, Vibrio cholera, and Escherichia coli (Walter et al., 2011). Most of the extracts showed better inhibition in lower concentrations.

9. Anti-inflammation

A study reported that an ethanolic extract of the M. concanensis flower and fruit inhibited inflammation by 78.4 and 44.08%, respectively (Rao et al., 2008; Jayabharathi and Chitra, 2011). An extract of the aerial part of M. peregrina decreased the effect of peritorial inflammation and reduced the permeability of small blood vessels (Elbatran et al., 2005). Ethanolic and aqueous extracts of M. peregrina seeds inhibited fresh egg albumin-induced acute inflammation in rats at doses of 100–300 mg/kg p.o (Koheil et al., 2011).

The major anti-inflammation mechanism reported for M. oleifera was the inhibition of the NF-κB pathway. Four fractions of M. oleifera leaf (hexane, chloroform, ethyl acetate, and butanol) reduced IL-1β, IL-6, PGE2, TNF-α, and nitric oxide production in LPS macrophages

 

 

 

 

 

 

 

Reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490473/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820334/

 

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Red-Stemmed Wild Grape - ampelocissus indica Medicinal use

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Red-Stemmed Wild Grape - ampelocissus indica

 

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Common name: Red-Stemmed Wild Grape-Vine • Kannada: ಚೆಂಬಳ್ಳಿ chemballi, ತಾಮ್ರವಲ್ಲಿ tamravalli • Malayalam: ചെന്പറവള്ളി cenparavalli • Marathi: रान द्राक्ष ran draksha • Tamil: சம்பாரவல்லி campara-valli • Tulu: ಚೆಂಬಳ್ಳಿ chemballi 

Synonyms

Ampelocissus arnottiana Planch.

Ampelopsis indica (L.) Bl.

Cissus indica (L.) Walp.

Vitis indica L.

Habitat

Peninsular India and Sri Lanka

 ampelocissus-indica-2.jpg

Morphology

 

Scandent shrub; branches striate, ferruginous-wooly. Leaves simple, broadly ovate, sometimes angled, cordate at base, dentate-serrate at margin with teeth hardened at tip, acuminate at apex, coriaceous, glabrescent above, ferruginous-hairy beneath; petioles 2-8 cm long.

Inflorescences dense racemes of umbels; primary branch ca 1 cm long; racemes 3-5 x ca 1 cm; peduncles to 5 cm long; tendrils simple, ca 10 cm long.

Flowers reddish brown; pedicels ca 2 mm long. Calyx saucer-like, entire, glabrous. Petals oblong-ovate, ca 2 mm long, glabrous. Disc elongate, covering most of ovary, 5-furrowed.

 

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Berries globose; seeds suborbicular in outline, mucronate at base, ca 7 x 5.5 mm, with a longitudinal ridge and a broad groove on either side on adaxial surface and an elliptic chalazal knot and very fine fissures radiating towards margin on abaxial surface.

 

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This plant traditionally used as an anti-inflammatory medicinal plant. It also shows diuretic activity.

 

 

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Reference

Phytochemical and pharmacological evaluation of ampelocissus

Shows gnificant anti-inflammatory activity that may be due to its inhibitory effect of histamine kinin and prostaglandins release

 

http://indiabiodiversity.org/species/show/252036

https://www.ncbi.nlm.nih.gov/m/pubmed/22557137/

Chatraka-Mushrooms (Agaricus campestris): Medicinal uses

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Chatraka-Mushrooms (Agaricus campestris)

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Mushroom Agaricus campestris is mentioned in Ayurveda for the treatment of fatigue, low sperm count. improving the sperm count. It is a good source of proteins, Vitamin B, K, C and D. 

Latin name- Agaricus campestris Linn.
Family- Agaricaceae
Synonyms: Psalliota campestris

Classical categorization:


Charaka Samhita –  Shaka varga

Bhela Samhita – Shaka varg
Bhavaprakasha Nighantu – Shaka varga, Samsvedaja Shaka
Adarsha Nighantu – Bhuchhatrakadi varga
Kaiyyadeva Nighantu – Aushada varga
Madana Pala Nighantu – Shaka varga
Dravya Guna Vijnaana – Samsvedaja Shaka varga
Raja Nighantu – Shalmalyadi Varga

 

Synonym:


Bhumi sphota, Prithvi sphota- Emerges from the earth

Shilindra- Emerges from the stones
Kutumbaka – appears in bunches
Bhumi chatra, Bhu Chatra- Umbrella shaped structure emerging from earth
Sarpa Chatra, Bhumi kanda, Malatruna, Sumali, Bhukanda, Prithvi kanda, Rohisha,

Reference of Mushroom in Ayurveda:


Bhela Samhitha Sutrasthana 28th chapter under shaka varga 24-26th shloka. Here he has mentioned about different types like palala jata Chatraka , venu Chhatraka, gomaya chhatraka  and their respective gunas also mentioned.

In Bhela Samhitha chikitsa sthana 2nd chapter 35th shloka. In jwara chikitsa, chhatraka is mentioned in a formulation called Mahapaishashika ghrata where it is an ingredient.

Types of mushrooms as per Ayurveda:
According to Bhela samhitha:

  • Palala jatha chhatraka
  • Gomaya chhatraka
  • Venu chhatraka

According to Kaiyyadeva nighantu:

  • Krishna chhatraka
  • Sarpa chhatraka
  • Shwetha chhatraka
  • Raktha chhatraka

Some other references: White, Red, Black
Savisha chhatraka – poisonous
Nirvisha chhatraka – non poisonous

Names in different languages:


Hindi name- Khumi, Gucchi, Chhata, Chhatona, Phenchhatar, Sanpakichhatri

English name- Mushroom
Arabic name- Fitar
Assamese name- Kalphula
Bengali name- Chhata, Chhatakuda, Bhuchhati
Gujarathi name- Viladino Topp, Kagdanachhatra,Mindadnivali
Marathi name- Alambi, Alombe, Kalambe, Khumba
Kannada name- Anabe
Tamil name- Naikkodai
Telugu name- Kukkagodugu
Catalan name – Bolet decam,Bolet comu
Chamba name – Moksha,Mopsha
French name – Psalliote champetre
German name – Brachpitz,Champigon
Hausa – Namanangulu, Namankassa
Kashmir name – Manskhel
Konkani name – Kamila
Persian name – Chatrimar
Portuguese name – Cogumelo
Punjabi name – Bleophore
Spanish name – Agarico camperino
Tulu – Lambu, Kallambu

 

 

Morphology of Agaricus campestris:


Chatraka belong to fungus kingdom. It grows wildly all over India near water source or in place of good moisture content in the soil. It is also cultivated for its commercial use and used in many cuisines. Mushroom has a weak mid part and an umbrella shaped top- hence the name Chatraka. Mushrooms are available in many shape and colors like pink, brown, pale white, white, black. Only some varieties are edible and some are poisonous.  

Agaricus campestris medicinal properties:
Rasa (Taste) – Madhura (Sweet)

Guna (Qualities) – Laghu (Light) Snigdha (Contain moisture), Picchila (Slimy)
Vipaka – Madhura  (Undergoes Sweet taste after digestion)
Veerya (Potency) – Sheeta (Cold)
Karma (Actions) –Vatapitta shamaka (reduces vitiated vata and pitta dosha),
Kaphavardaka ( increase kapha dosha)

Part used- Whole fungus
Dosage- According to the requirement

Chemical constituents of Agaricus campestris:
A protein (2.75%) supplement and an excellent source of vitamins of B complex. Vitamins K, C and D are also present. Though all the amino acids are reported to be present, the concentration of tryptophane is particularly low.

Uses of Chatraka:

  • Chatraka is mainly used like vegetable in cuisines all over the world.
  • Chatraka is boiled and is consumed with ghee to improve the sperm count.
  • Mushroom is cut into small pieces and boiled in milk. This boiled milk is consumed in conditions of emaciation of the body and to improve the physical strength.
  • In conditions of hyperacidity, mushroom is taken along with ghee or sugar candy.
  • Little quantity of chatraka is taken with sugar candy in treating dry cough.
  • Mushroom is fried with ghee and consumed to improve the sexual vigor.

 

Description of mushrooms as per Ayurveda:
White variety, clean, with the colour of bamboo, cow are good to eat. They do not increase Doshas, unlike other types of mushrooms.

Other mushrooms are heavy, can cause vomiting, diarrhea, fever and Kapha disorders.

Madhura – sweet
Vrushya – Aphrodisiac, improves sexual strength
Balya – improves strength and immunity
Rooksha – dry
Hima – coolant
Guru – heavy to digest
Durjara – heavy and hard to digest
Bhedana – may cause diarrhea
Tridoshala – can increase all three Doshas

The dwarf variety is astringent, Katu Vipaka (pungent taste conversion after digestion).
Black mushroom is sweet taste and Vipaka,
White musrhoom is guru – heavy to digest
Red mushroom can increase Doshas by small extent

Adverse effects:
Some varieties of mushroom are poisonous and cause loss of sensation, diarrhea, nausea, vomiting, allergic rashes over the body, swollen lips, cramps of the muscles etc. Hence care should be taken to select the proper variety of mushroom.

 

Research articles related to Agaricus campestris:


Anti- oxidant potential: The chemical, bioactive, and antioxidant potential of twenty wild culinary mushroom species being consumed by the people of northern Himalayan regions has been evaluated for the first time in the present study. Although differences were observed in the net values of individual species all the species were found to be rich in protein and carbohydrates and low in fat. Glucose was found to be the major monosaccharide. Predominance of UFA (65–70%) over SFA (30–35%) was observed in all the species with considerable amounts of other bioactive compounds. All the species showed higher effectiveness for antioxidant capacities.

Anti- bacterial study: Antibacterial activity of methanolic and acetone extracts of Agaricus bisporus were determined in-vitro against two pathogenic bacteria Escherichia coli and Staphylococcus aureus following agar well diffusion method using different concentrations (25, 50, 75 and 100%). Methanolic and acetone extracts showed potent antibacterial activity against tested bacteria. Methanolic extract showed maximum inhibitory effect against growth of each of the test bacterium.

 

 

Country borage (Parnayavani-Plectranthus amboinicus) Medicinal uses

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Country borage (Parnayavani-Plectranthus amboinicus)

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Parnayavani- Plectranthus amboinicus is an plant mentioned in Ayurveda for the treatment of cough, asthma, headache, indigestion, diarrhea and intestinal worms. 

Latin name- Coleus amboinicus Lour. Plectranthus amboinicus
Family- Labiatae

Names in different languages:
Hindi name- Patta ajwayin, Amroda, Patherchur , pathercheer

English name- Country borage, Indian mint, Indian borage
Bengali name- Pathar choor, Paterchur,Amalkuchi
Gujarathi name- Ovapan
Kannada name- Dodda patre, Sambrani, Sambrani soppu
Malayalam name- Panikoorka
Marathi name- Pan ova
Tamil name- Karpooravalli, Kurpurvallai
Telugu name- Karuvacru, Suganda vallekam, Karpoorvalli
French name   :Coleus d’Afrique , Plectrianthus aromatique
German name : Cubanischer oregano,Jamaican Thymian
Japenese name Koreusu amboinikusu , Kuuban oregano
Malay name  : Daun kucing (Indonesia) , Daun Kambing(Indonesia)
Russian name : Plektrantus aromatryi
Spanish name  : Oregano
Vietnamese name:Tan day le
Mah            :Pan-ova
Gujarathi name – Ovapana
Chinese name – Zuo Shou Xiang

 

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Synonyms:
Chornika, Karpooravalli, Sugandhi, Parnika, Himasagar, Ashmari bheda

Parnayavani is a small plant growing to a height of 1- 2 feet. The stem is fleshy but has less strength. The leaves are little oval, thick, fleshy and have hair like structure beneath with strong odor. The flowers are small, purple colored and are seen in the month of May- July. The plant is available and cultivated all over India in the temperate climate.

Properties:
Rasa (Taste) – Katu (Pungent), Tikta (Bitter)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka –  Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf
Dosage- 5 to 10 ml of juice

Chemical constituents of Plectranthus amboinicus
The aerial parts of the plant yield an essential oil (0.1%) which contains thymol (79.5%); whereas in leaves carvacrol and camphor are major constituents. Leaves also contain a large amount of oxalacetic acid, flavonoid, cirsimaritin and beta- sitosterol.

तीक्ष्णा पर्णयवान्युष्णा कटुतिक्ता रसे लघुः । दीपनी पाचनी रुच्या मलसंग्राहिणी परम् ॥
अग्निमान्द्ये यकृद्रोगे ग्रहण्यामुदरक्रिमौ । विषूचिकायामश्मर्या मूत्रकृच्छ्रे च शस्यते॥      ( द्र.गु.वि)

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Uses of Indian borage:

  • The juice from the crushed leaves of Parnayavani is given in a dose of 5 -6 ml with honey to treat cough and rhinitis.
  • The fresh juice of Coleus amboinicus is given in dose of 10 ml with hot water to treat intestinal worms.
  • The juice of the plant is given with juice of ginger to improve appetite and treat indigestion.
  • The paste and juice of the leaf is given internally to treat renal and urinary calculi.
  • The juice of Parnayavani is given with decoction of Kutaja (Holarrhena antidysentrica) to treat diarrhea and irritable bowel syndrome.
  • The paste of the leaf is applied over forehead to treat headache.
  • Expressed juice of leaf  is applied around the orbit to relieve the pain in conjunctivitis
  • Juice is mixed with sugar is given to children in colic, in asthma, chronic cough, strangury, calculus, gonorrhoea, piles and dyspepsia
  • Crushed leaves are used as local application to the head in headache and to relieve the pain and irritation caused by centipedes
  • Expressed juice is applied around the orbit to relieve the pain in conjunctivitis
  • The drug is also useful in cardiac disability,cough,breathlesness,hiccups,dysurea and urinary calculi
  • Expressed juice of leaves are carminative and used in dyspepsia
  • The drug is used in vatavyadhi(akshepaka, apatantraka).It is also considered as useful in hridroga
  • This drug is diuretic herbal agent. Its leaves have a plesant odour and pungent taste
  • The drug is quite useful in disorders of digestive system,particularly gastrointestinal complaints.

Adverse effects of country borage:
No adverse effect is known after the use of parnayavani. Some people suffer from burning sensation of the tongue and esophagus after the intake of juice of the leaf.

Ayurvedic medicines containing Coleus amboinicus
Byekof syrup: Byekof Syrup is a proprietary Ayurvedic medicine useful to treat cough, asthma and other respiratory disorders.

Grahanimihira taila: Grahanimihira Taila is an Ayurvedic oil used in the treatment of diarrhea, fever, cough, etc. This oil is used both for external and internal administration.

 

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Research articles related to Coleus amboinicus:
Anti- microbial study:  Ethanolic extract of Coleus amboinicus leaves were used for study of antimicrobial activity. The antimicrobial activity was evaluated against six bacterial strains with four different concentrations by detecting minimum inhibitory concentration and zone of inhibition. The highest antibacterial activity was observed in Salmonella typhi at a concentration of 1000µg/ml. The lowest antibacterial activity was observed in Staphylococcus aureus at a concentration of 250µg/ml of ethanolic extract of Coleus amboinicus leaf extract.

Anti- bacterial  and Anti- fungal action:  The aim of this study was to evaluate anti-bacterial anti-fungal activity of six Lamiaceae family coleus plants based on their traditional uses (breast-milk stimulants) from two Asian countries. All leaf extracts showed activity at least against one strain of bacteria and the result shows that there were significant differences (p<0.05) between the activities on microorganism. The minimum inhibitory concentration of all leaves extracts ranged from 1.0 to 2.0 mg/ml in inhibiting the growth of S. aureusE. coliP. aeruginosa and B. subtilis. This study shows that the coleus plants leaves can be used as anti-bacterial anti-fungal agent apart from the breast-milk stimulation properties.

Anti- oxidant and cytotoxic action: The aetylacetate and ethanolic extracts of Plectranthus amboinicus, (Lour.) Spreng. Leaves were found to exhibit antioxidant activity with IC50 value 350.74 µg/mL and 281.26 µg/mL by DPPH method. The ethanolic and aetylacetate extracts showed a high antioxidant activity by ß-Carotene-Linoleic Acid Method. N-hexane and aetylacetate extracts showed potent cytotoxic effect on MCF7 with IC50 63.644 µg/mL, 7.647 µg/mL respectively.

Classical categorization:
Priya Nighantu- karpooradi varga

Scientific classification
Kingdom: Plantae
Order: Lamiales
Family: Lamiaceae
Genus: Plectranthus
Species: P. amboinicus

 

Jupha (Hyssopus officinalis) Medicinal uses

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Jupha  (Hyssopus officinalis)

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Jupha- Hyssopus officinalis is a plant used for the treatment of swelling, constipation, distention of the abdomen, intestinal worms, hepatomegaly, cough and rhinitis. 

Latin name- Hyssopus officinalis Linn.
Family-Laiatae

Names in different languages:
Hindi name – Jupha

English name – Hyssop
Malayalam name – Isop
Urdu name – Zufah
Chinese – Ngau sat chou
Dutch – Hysop
French – Hysope, Hese saesu
German – Eisop
Greek – Issopos
Hebrew – Esuv
Hindi – Jupha,
Iceland – Isopus
Italian – Issopo
Japanese – Hissopu
Korean – Harob
Norwegian – Hissopo
Russian – Issop
Spanish – Hisopo
Swedish – Isop

Morphology of Hyssopus officinalis:


Jupha is a small plant spreading in the ground level and is found in the Himalayan belt. The stem is woody at the base, from which grow a number of straight branches. Its leaves are lanceolate, dark green in color, and from 2 to 2.5 cm (0.79 to 0.98 in) long. The leaves have small hair like structure and have a pleasant odor and bitter taste. The flowers are pinkish to purplish in color and have pleasant odor.  They bloom from July to September. The fruit is brown in color and slightly triangular in shape.

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Properties:


Rasa (Taste) – Katu (Pungent), Tikta (Bitter)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Whole plant
Dosage- 3 to 6 g powder

 

Chemical constituents of Hyssopus officinalis:
Hyssop contains terpenoids, including marrubiin; a volatile oil consisting mainly of camphor, pinocamphone and beta-pinene; flavonoids, glucosides, tannins and resin. Marrubiin is a strong expectorant. The plant also contains ursolic acid, an anti-inflammatory principle. The alcoholic extract of the aerial parts at flower- ing yields an active antioxidant com- pound, rosmanol-ethyl ether. Its activity is much greater than butylated hydroxyl toluene. Pinocamphone and isopino camphone are toxic constituents of the essential oil.

जूफा तीक्ष्णा कटुतिक्ता वीर्योष्णा कफवातनुत् ।
शोथघ्नी लेखनी पित्तसारणी कृमिनाशिनी॥   ( द्र.गु.)

 

 

Gana – Traditional classification: 
Tulasyadi Varga- Adarsha Nigantu

 

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Uses of Jupha:

  • A tea made from the leaves is used in the treatment of flatulence, stomach aches, upper respiratory tract infections, and coughs in children.
  • A poultice made from the herb is used to heal wounds.
  • The paste of the leaf is applied over wound for healing.
  • Cold infusion of the leaf is given in a dose of 40 ml to treat hepatomegaly and fever.
  • The paste of the leaf is applied over the forehead to treat rhinitis and headache.
  • Fresh juice of the leaf and flower is given in a dose of 10 ml to treat constipation and distention of abdomen.
  • The decoction of the leaf is given in a dose of 25 ml to treat intestinal worms.
  • The juice of the leaf is given with honey to treat cough and asthma.
  • The essential oil is used in aromatherapy. This oil should not be used on people who are highly strung as it can cause epileptic symptoms. This oil should not be used internally expect under professional supervision.
  • Externally used as a re-solvent particularly for ecchymosis of eye and eyelids. Oil is used to treat cold cough and lung complains.

 

 

Adverse effect of Hyssop: The essential oil of the plant in excess quantity can cause increased intestinal movement and diarrhea. Apart from the above features it can also cause epileptic attack in person susceptible to strong odor.

Ayurvedic medicines containing Jupha:
Gojihwadi kashaya: It is an Ayurvedic medicine in water decoction form. It is used in the treatment of fever, cough, bronchitis, asthma etc.

P-KOF syrup: P-KOF Syrup is a proprietary Ayurvedic medicine indicated in Ayurvedic treatment of cold, cough and allergic conditions.

Research articles related to Hyssopus officinalis:


Anti- asthmatic action: It has been proved that Uygur herb Hyssopus offcinalis L. could affect the levels of some cytokines (such as IL-4, IL-6, IL-17, and IFN-γ) in asthmatic mice. By detection of the expressions of MMP-9 and TIMP-1 and the morphological changes, the aim of this research is to reveal the mechanism of Uygur herb Hyssopus offcinalis L. in the process of airway remodeling. It is suggested that Uygur herb Hyssopus offcinalis L. could inhibit airway remodeling by correcting imbalance of MMP-9/TIMP-1 ratio.

Ulcero protective action: Ethanolic extract of Hyssopus officinalis (EEHO) at the dose of 100 and 125 mg/kg was administered to albino rats 1 hour before the administration of ethanol. Animals were there then sacrificed and tissue homogenate was used for various biochemical parameters in order to explore the ulcero- protective and antioxidant potential of the plant. Administration of 1 ml of ethanol to overnight fasted rats resulted in increased ulcer index, total acidity and decreased pH.  The findings of the study indicate that pre-treatment with EEHO has a significant ulcero- protective and antioxidant activity in ethanol-induced ulcers.

 

 

Pudina (Mentha piperita) Medicinal uses

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Pudina (Mentha piperita)

Pudina -Mentha-piperita-4.jpg

 

Pudina – Mentha piperata is a plant which is used for the treatment of indigestion, pain in joints, diarrhea, cough, dysmenorrhea and fever.  

Latin name- Mentha piperata Linn. Mentha spicata
Family- Labiate

Names in different languages:


All the Indian languages like Hindi, Bengali, Kannada, Gujarathi, Malayalam, Tamil, Telugu etc use the name Pudina for the plant. In English the plant is known as Spearmint or Garden mint.

Arabic – Phujanaj
Bengali name – Pudina
Burmese name – Bhudina
Canada – Chetni-maruga
Hindi – Podina
Malayalam – Putina
Marathi name – Pudina

Synonyms:


Rochani- Improves the taste perception

Pahari- Grow in the cool climate of hills
Pudina, Putiha, Pudina, Podinaka, Phudino, Podina

Classical categorization:


Bhavaprakash Nighantu – Anekaryanam varga
Nighantu Adarsha – Putikaranjadi varga
Dhanavantari Nighantu – Suvarnadi varga

 

Pudina -Mentha-piperita-1.jpg

Morphology:


Mentha piperata is a perennial herb growing in the hilly regions or in the cold climatic regions of India. The plant has a strong odor and grows to a height of 1-2 foot. The leaves are slimy, dark and have a strong odor. The flowers are purple in color.Mentha spicata is also used as a synonym for Mentha piperata.

Pudina (Mentha piperita) medicinal properties:


Rasa (Taste) – Katu (Pungent)

Guna (Qualities) – Laghu (Light for digestion), Ruksha (Dry in nature), Teekshna (Strong)
Vipaka – – Katu (Undergoes Pungent taste after digestion)
Veerya (Potency) – Ushna (Hot)
Karma (Actions) – Kaphavata shamaka (reduces vitiated kapha and vata dosha)

Part used- Leaf, oil extract
Dosage-
Leaf juice- 5 to 10 ml

Cold infusion- 25 to 30 ml
Oil- 1 to 3 drops

Chemical constituents of Mentha piperata:


The major constituents of the essential oil are: menthol, menthone, pule- gone, menthofuran, 1,8-cineole, menthyl acetate, isomenthone. The leaves contain flavonoid glycosides, eriocitrin, luteolin 7-O-rutinoside, hesperi- din, isorhoifolin, diosmin, eriodictyol 7-O-glucoside and narirutin, besides rosmarinic acid, azulenes, cholene, carotenes.

रोचनी वह्रिजननी वक्त्रजाड्यनिशूदनी |
कफवातहरी बल्या चर्द्यर्ह्रोचकवारिणी॥      ( आ. वि)

 

Medicinal uses of mint leaves: 

  • Pudina is used in many cuisines all over the world, to enhance the taste of the dish.
  • The leaves of Mentha piperata is used as carmative and helps in digestion of the food.
  • 1-3 drops of oil obtained after the processing from the plant is used with hot water to treat indigestion and relive colic pain.
  • The paste of the leaf of Mentha piperata is applied over the joints to relive pain and localized inflammation.
  • Cold infusion of the plant in a dose of 30-40 ml is used to relieve dysmenorrhea and fever.
  • The fresh juice of the leaf of Pudina, in a dose of 5 to 10 ml is given with honey to relieve cough and sore throat.
  • The paste of the leaf is applied over the skin to relieve itching sensation and wound associated with pus.
  • The distillate of the leaf is extracted and used in a dose of 1 to 3 drops with hot water to treat indigestion and bloating of abdomen.
  • Gargling is done by adding fresh juice of the leaf of Pudina with water to relieve bad odor from the mouth and treat inflammation of the gums.
  • The paste of the leaf of Pudina is given with first morsel of food to treat intestinal worms.

Pudina -Mentha-piperita-2.JPG

Adverse effect:


Although it is used in many consumer products, mint may cause allergic reactions in some people, inducing symptoms such as abdominal cramps, diarrhea, headaches, heartburn, tingling or numbing around the mouth, anaphylaxis or contact dermatitis.

Formulations containing Putiha:


Antharth oil and liniment: It is a proprietary medicine useful to relive joint pain, reduce morning sickness and localized inflammation after external application.

Appirich syrup: Appirich Syrup is a proprietary Ayurvedic medicine useful as an appetizer in children. It improves taste in food and makes the child to feel hunger and eat well.

Calcurosin syrup: It is a proprietary Ayurvedic medicine useful to treat urinary bladder calculi and kidney stones.

Capsin cream: It is a cream used for external application in treating joint pain, muscle spasm and arthritis.

Kofsil syrup: Kofsil Syrup is a non-sedative herbal cough syrup. It is used in the treatment of bronchial asthma, bronchitis, bronchospasm, allergic asthma and smoker’s cough.

Acidowin tablet: It is a proprietary Ayurvedic medicine useful to treat hyperacidity, flatulence, reflux oesophagitis and motion sickness.

Cultivars variety

Mentha × piperita 'Candymint'. Stems reddish.
Mentha × piperita 'Chocolate Mint'. Flowers open from bottom up; reminiscent of flavour in Andes Chocolate Mints, a popular confection.
Mentha × piperita 'Citrata'. Includes a number of varieties including Eau De Cologne Mint, Grapefruit Mint, Lemon Mint, and Orange Mint. Leaves aromatic, hairless.
Mentha × piperita 'Crispa'. Leaves wrinkled.
Mentha × piperita 'Lavender Mint'.
Mentha × piperita 'Lime Mint'. Foliage lime-scented.
Mentha × piperita 'Variegata'. Leaves mottled green and pale yellow.
"Mentha suaveolens" 'Apple Mint'. Foliage is light green and hairy. Used as a ground cover and for cooking

 

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Research articles related to Mentha piperata:


Anti-bacterial action: The antibacterial activity of peppermint oil and different extracts of Mentha piperita against some Gram-positive and Gram-negative bacterial strains was evaluated in the present research work by agar well diffusion method. The oil and extracts also exhibited significant antioxidant activity and the oil showed about half potency when compared to the standard BHT.

Anti- diabetic action: The present study was undertaken with an objective to observe effectiveness of oral administration of Peppermint juice in alloxan induced diabetic wistar rats. The present experimental study provides further evidence that oral administration of Peppermint juice for 21 days produced a significant decrease (p <0.0010) in the blood glucose level of alloxan induced diabetic rats.

Wound healing action: The objective of this study was to evaluate the effects of topical Mentha piperita and Cymbopogan citratus oil on wound healing. Diabetic induced infected wound treatment with topical Mentha piperita ointment treatment and their another essential ointment in Cymbopogan citratus wound contraction studies a circular piece08 mm2 in area 20th days compared wound healing study on the wound contraction studies a circular piece 08mm2 in area 18th days highly effective in Mentha piperita ointment.

Anti- fungal action: Essential oil of Mentha piperita was analyzed by GC and GC-MS and evaluated for in vitro antifungal activity against Dreschlera spiciferaFusarium oxysporum f.sp. ciceris and Macrophomina phaseolin. The oil was found to be effective against these fungal pathogens under laboratory screening. The antifungal activities of the oil increased with an increase in the concentration.

Anti-emetic action in chemotherapy: This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha × piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV). The treatment and placebo groups applied essential oils of M. spicata, M. × piperita, or a placebo, while the control group continued with their previous antiemetic regimen. There was a significant reduction in the intensity and number of emetic events in the first 24 h with M. spicata and M. × piperitain both treatment groups (p < 0.05) when compared with the control and no adverse effects were reported. The cost of treatment was also reduced when essential oils were used.

 

 

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